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Protective effects of buflomedil on sciatic nerve crush lesion in rats


, : Protective effects of buflomedil on sciatic nerve crush lesion in rats. Zhongguo Xinyao yu Linchuang Zazhi 27(6): 425-428

AIM Study on protective effects of buflomedil to sciatic nerve crush lesion in rats. METHODS One hundred SD rats were randomly divided into normal group, model group, mecobalamin group (104 mu g.kg(-1)), and buflomedil group (40 mg.kg(-1)). Sciatic nerve crush lesion model were established in rats. The conduction velocity of sciatic nerve and the morphological changes were observed by light and electron microscope. RESULTS At the end of 4 weeks, the conduction velocity of buflomedil group increased obviously as well as methycobal group, with significant difference (P < 0.05, P < 0.01). Almost normal myelin was observed in the buflomedil group and mecobalamin group, and the severe degeneration was observed in the model group. CONCLUSION Buflomedil shows recovery effects on the sciatic nerve crush lesion.

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