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Protective effects of levosimendan and iloprost on lung injury induced by limb ischemia-reperfusion: a rabbit model


, : Protective effects of levosimendan and iloprost on lung injury induced by limb ischemia-reperfusion: a rabbit model. Journal of Surgical Research 147(1): 138-142

Background. The aim of this study was to clarify whether levosimendan could prevent lung tissue injury from limb ischemia/reperfusion.Methods. The common femoral arteries of 50 New Zealand white rabbits, both male and female, each weighing about 3 kg, were clamped and 1 h of ischemia followed by 4 h of reperfusion. In an attempt to decrease reperfusion injury, the rabbits were given levosimendan in Group A. In Group B, iloprost was infused at the same period. A similar value of saline solution was given in the control group, Group C correspondingly. Levosimendan and iloprost were given together the Group E, and Group D was sham group without medication and ischemia. Blood pH, pO2, pCO2, HCO3, Na, K, creatine phosphokinase, lactate dehydrogenase values were determined at the end of the reperfusion period. Malondialdehyde (MDA) was measured in plasma and lung as an indicator of free radicals. Hemodynamics parameters were noted for each group. After the procedure, left lung tissues were taken for histopathologic study.Results. Blood PO2 and HCO3 levels were significantly higher (P < 0.05) and creatine phosphokinase, lactate dehydrognase, and MDA levels were significantly lower (P < 0.05) in Groups A, B, D, and E compared with Group C. Similarly, the MDA levels in the lung tissue and plasma levels were significantly lower in the treatment groups compared with the control group (P < 0.05). Lung damage was significantly higher in Group C. There was no significant difference between groups in other parameters.Conclusions. The results suggest that levosimendan and iloprost are useful for attenuating oxidative lung damage occurring after a period of limb ischemia/reperfusion.

US$19.90

PMID: 18222476

DOI: 10.1016/j.jss.2007.08.002


Other references

Kidd, J.N.; Jackson, R.J.; Smith, S.D.; Wagner, C.W., 2003: Evolution of staged versus primary closure of gastroschisis. Since the introduction of a preformed silo to the authors' practice in 1997, there has been a decrease in primary closure of gastroschisis. To clarify the impact of this change, the authors reviewed their results over the past 10 years. From...

Fayyaz M.M.; Mccown B.H.; Beck G.E., 1974: Cold hardiness in various parts of chrysanthemum morifolium. Hortscience 9(3 SEC 2): 270

Gambolati Giuseppe; Teatini Pietro, 1998: Natural land subsidence due to sediment compaction of the upper Adriatic Sea basin. GEAM Geoingegneria Ambientale e Mineraria

Sowinski, J.; Czaykowski, L.E., 1962: Surgical osteoarticular tuberculosis. Chirurgia Narzadow Ruchu i Ortopedia Polska 27: 179-190

Strick P.L., 1988: Origin and density of corticospinal cst projections from the premotor areas of macaques. Society For Neuroscience Abstracts: 821

Andersen, J.B.; Thorgeirsson, S.S., 2012: Genetic profiling of intrahepatic cholangiocarcinoma. Intrahepatic cholangiocarcinoma (ICC) is a treatment-refractory disease with a dismal outcome. Limited success in the clinical management and a persistent increase in the incidence world-wide have made ICC one of the most lethal and fastest growin...

Friedman, A.H.; Wilkins, R.H.; Kenan, P.D.; Olanow, C.W.; Dubois, P.J., 1982: Pituitary adenoma presenting as facial pain: report of two cases and review of the literature. Neurosurgery 10(6 Pt 1): 742-745

Gao Zhong he; J.Y.u ting; X.Y.ng shen; Chen Xiao ming; Qin Cheng chang, 1991: Discovery of the beachrock in Xiangshan of Zhejiang Province and its significance. Dizhen Dizhi = Seismology and Geology 13(1): 28-32

Moya, M.; Domenech, E., 1980: Importance of formula Ca/Pi ratio on calcium balance in the low birthweight infants during the first three days of life. Infants artificially fed were 10 given feed with calcium/phosphorus quotient 2.4, 9 infants with quotient 1.6 and 5 infants given the same feed as the 1st group but with calcium lactate added to give a Ca/P quotient of 4.2. The 1st feed had signif...

Stadler, P.; Blum, A.L., 1989: Is Campylobacter pylori responsible for ulcer disease?. Gastroenterologie Clinique et Biologique 13(1): 3-7