geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Protective effects of sericin protein on alcohol-mediated liver damage in mice


, : Protective effects of sericin protein on alcohol-mediated liver damage in mice. Alcohol and Alcoholism 43(3): 246-253

Aims: The purpose of this study was to investigate the protective effects of sericin protein (SP) on alcohol-induced hepatic injury in mice and the possible mechanisms. Methods: SP (0.375, 0.75 and 1.50 g/kg body weight) was dissolved in distilled water and given to mice by gavage 1 hour before the alcohol (56% wt/vol, 14.2 ml/kg b.w.) treatment for 30 days, then blood, urine and liver were collected, processed and used for alcohol concentration mensuration, various biochemical estimations and histopathological examination. Results: The concentration of alcohol evidently decreased in serum and increased in urine in SP treated mice as compared to alcohol-administered animals. Chronic alcohol administration resulted in significantly increase in the levels of transaminase (AST and ALT) and malondialdehyde (MDA) but decrease of glutathione (GSH), glutathione peroxidase (GSH-PX), catalase (CAT) and superoxide dismutase (SOD) in the serum and liver. Hepatic triglyceride (TG) also increased. When mice ingested high doses of SP (0.75 and 1.50 g/kg b.w.) the levels of antioxidant enzymes in the serum were restored to normal. However, hepatic CAT and GSH were still below normal, although a trend of significant increases was observed in comparison with alcohol treatment group. Conclusions: The results indicated that SP was able to hasten the alcohol elimination through urine directly and enhance the ethanol oxidation rate in liver. Simultaneously, SP may exert a protective effect against lipid peroxidation by scavenging reactive oxygen species and elevating the activity of antioxidant enzymes, in consequence prevented the peroxidative deterioration of structural lipids in membranous organelles, especially mitochondria and karyon.

US$19.90

PMID: 18263900

DOI: 10.1093/alcalc/agm164


Other references

W.G.angFeng; Sha Jie; Shi Ying, 2007: Review on the monitoring of heat damage in milk during heat treatment. This article summarizes the chemical reactions in milk during heat treatment, analyses the properties of several indicators of heat damage, such as heat-sensitive enzymes, denatured proteins, the products of Maillard reaction and isomerized lactos...

Yonemura, S., 2017: Actin filament association at adherens junctions. The adherens junction (AJ) is a cadherin-based and actin filament associated cell-to-cell junction. AJs can contribute to tissue morphogenesis and homeostasis and their association with actin filaments is crucial for the functions. There are three...

Kreutzberger, A.; Esser, E., 1984: Synthesis and trichomonacidal activity of di(isopropylamino)-1,3,5-triazines. Archiv der Pharmazie 317(9): 754-759

Riechman, S.E.; Dabayebeh, I.; Balasakeran, G.; Goss, F.L.; Moore, G.E.; Robertson, R.J., 1999: Absence of a beta-endorphin mediating effect for RPE and mood at sub-maximal exercise intensities. Medicine & Science in Sports & Exercise 31(5 SUPPL ): S84, May

Charles D.J.; Simon J.E., 1991: Volatile compounds of the curry plant. The curry plant [Helichrysum italicum (Roth) G. Don in Loudon ssp. italicum or H. angustifolium (Lam.) DC (Asteraceae)], a popular ornamental herb with a curry-like aroma, was chemically evaluated to identify the essential oil constituents respons...

Monteiro, A.M., 1951: Economic and social aspects of the problem of nutrition of the Brazilian employee in commerce. Imprensa Medica 27(454): 63-80

Wang, W., 2015: The diagnostic strategy for and cases analysis of oral mucosa-related syndrome. Zhonghua Kou Qiang Yi Xue Za Zhi 49(8): 449-453

Cookson, I.C.; Eisenack, A., 1965: Microplankton from the Dartmoor Formation, SW. Victoria. Proceedings of the Royal Society of Victoria, 79: 133-138

Singh, K.D.; Tripathi, S.N.; Pandey, A.K., 2004: Economic-viability of sequential cropping systems under non-saline calcareous soil of Bihar. An experiment was conducted at the CTRI Research Station, Pusa, Bihar, during 1994-95, 1996-97 and 1997-98 on sandy loam (alluvial), non-saline calcareous soil (pH 8.2) under irrigated condition. Treatments consisted of 12 tobacco (Nicotiana tabac...

Han, X.Y.n; Wang, W.; Myllyla, R., 1999: MRNA levels for a-subunit of prolyl 4-hydroxylase and fibrillar collagens in immobilized rat skeletal muscle. Journal of Applied Physiology 87(1): 6