geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Protective efficacy of a recombinant DNA vaccine against hepatitis B in male homosexuals: results at 36 months


, : Protective efficacy of a recombinant DNA vaccine against hepatitis B in male homosexuals: results at 36 months. Vaccine 8 Suppl: S50-2; Discussion S60-2

An open study with a recombinant DNA yeast-derived hepatitis B vaccine (YDV) was carried out in homosexual men to assess the protective efficacy of this vaccine. A total of 278 seronegative volunteers were enrolled to receive three intramuscular doses of either 20 or 40 micrograms at months 0, 1 and 6. Serum specimens were taken at various times up to 36 months; relevant information regarding the occurrence of other sexually transmitted diseases (STDs) and sexual behaviour was also collected annually. One month after the third injection, the seroconversion rate in both groups was 99%. The geometric mean anti-HBs titre at this time was higher for subjects receiving 40 micrograms doses although a similar percentage of the vaccinees had titres greater than 10 mIU ml-1 in both groups. Compared with a historical control group in which the annual incidence of hepatitis B infection was 12%, only two vaccinees developed markers of infection during the immunization period and none thereafter. While an important increase in the use of condoms was noted during the 1984-87 study period and the incidence of some STDs declined, these changes could not solely account for the decrease in hepatitis B infection in the study population.

US$19.90

PMID: 2139284

DOI: 10.1016/0264-410x(90)90219-c


Other references

Bauer, H.R., 1977: Chimpanzee bipedal loco motion in the gombe national park east africa. An adult male chimpanzee in the natural habitat was observed to walk predominantly bipedally after a total forelimb paralysis in 1966. The major differences from previously described bipedal chimpanzee gait are: 1/3 of the femoral extension was po...

Pinheiro, M.R.; Lima, M.S.; De-Melo, D.F.; Peter, H.W., 1988: Activation of the f 1 atpase in mitochondria of vigna unguiculata l. walp. cultivar pitiuba by potassium. Mitochondria from the bean Vigna unguiculata contain an ATPase system that is strongly activated by K+ and Na+ in the presence of low concentrations of substrate. Optimum activation by physiological concentrations of K+ is achieved in the presence...

Wells, A.J.; Hoffman, J.R.; Jajtner, A.R.; Varanoske, A.N.; Church, D.D.; Gonzalez, A.M.; Townsend, J.R.; Boone, C.H.; Baker, K.M.; Beyer, K.S.; Mangine, G.T.; Oliveira, L.P.; Fukuda, D.H.; Stout, J.R., 2016: Monocyte Recruitment after High-Intensity and High-Volume Resistance Exercise. The innate immune response is generally considered to have an important role in tissue remodeling after resistance exercise. The purpose of this study was to compare changes in markers of monocyte recruitment after an acute bout of high-intensity...

Serel, T.A.; Kecelioglu, M., 2000: Serum insulin-like growth factor is not a useful marker of prostate cancer. Bju International 85(4): 559-560

North W.A., 1975: Estrogens in native pines and livestock ponds. Journal of Animal Science 40(1): 186

Larsen, K.; Sørensen, K.K.; Gammeltoft, S.; Jensen, K.J., 2009: General solid-phase phosphopeptide proteomis with affinity pull-down. Advances in Experimental Medicine and Biology 611: 215-216

Nie, M.; Balda, M.S.; Matter, K., 2012: Stress- and Rho-activated ZO-1-associated nucleic acid binding protein binding to p21 mRNA mediates stabilization, translation, and cell survival. A central component of the cellular stress response is p21(WAF1/CIP1), which regulates cell proliferation, survival, and differentiation. Inflammation and cell stress often up-regulate p21 posttranscriptionally by regulatory mechanisms that are po...

Chasan R., 1992: When less is more using deletions to clone genes. Plant Cell 4(2): 111-112

Krebs, A.; Ulber, H., 1960: On the effect of sulfuric acid pretreatment on the result of tubercle bacteria demonstration in culture. Zeitschrift für Arztliche Fortbildung 54: 620-623

Bourdeau-Sisco, P.S., 1952: Woman's medical society of Maryland; the history of Branch Three. Journal of the American Medical Women's Association 7(11): 417-418