geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Protective efficacy of standard Edmonston-Zagreb measles vaccination in infants aged 4.5 months: interim analysis of a randomised clinical trial


, : Protective efficacy of standard Edmonston-Zagreb measles vaccination in infants aged 4.5 months: interim analysis of a randomised clinical trial. Bmj 337: A661-A661

Objective To examine the protective efficacy of measles vaccination in infants in a low income country before 9 months of age.Design Randomised clinical trial.Participants 1333 infants aged 4.5 months: 441 in treatment group and 892 in control group.Setting Urban area in Guinea-Bissau.Intervention Measles vaccination using standard titre Edmonston-Zagreb vaccine at 4.5 months of age.Main outcome measures Vaccine efficacy against measles infection, admission to hospital for measles, and measles mortality before standard vaccination at 9 months of age.Results 28% of the children tested at 4.5 months of age had protective levels of maternal antibodies against measles at enrolment. After early vaccination against measles 92% had measles antibodies at 9 months of age. A measles outbreak offered a unique situation for testing the efficacy of early measles vaccination. During the outbreak, 96 children developed measles; 19% of unvaccinated children had measles before 9 months of age. The monthly incidence of measles among the 441 children enrolled in the treatment arm was 0.7% and among the 892 enrolled in the control arm was 3.1%. Early vaccination with the Edmonston-Zagreb measles vaccine prevented infection; vaccine efficacy for children with serologically confirmed measles and definite clinical measles was 94% (95% confidence interval 77% to 99%), for admissions to hospital for measles was 100% (46% to 100%), and for measles mortality was 100% (-42% to 100%). The number needed to treat to prevent one case of measles between ages 4.5 months and 9 months during the epidemic was 7.2 (6.8 to 9.2). The treatment group tended to have lower overall mortality (mortality rate ratio 0.18, 0.02 to 1.36) although this was not significant.Conclusions In low income countries, maternal antibody levels against measles may be low and severe outbreaks of measles can occur in infants before the recommended age of vaccination at 9 months. Outbreaks of measles may be curtailed by measles vaccination using the Edmonston-Zagreb vaccine as early as 4.5 months of age.Trial registration Clinical Trials NCT00168558 [ClinicalTrials.gov].

US$29.90

PMID: 18653640


Other references

Enmon, R.M.Jr.; O'connor, K.C.; Lacks, D.J.; Schwartz, D.K.; Dotson, R.S., 2001: Dynamics of spheroid self-assembly in liquid-overlay culture of DU 145 human prostate cancer cells. The in vitro self-assembly of multicellular spheroids generates highly organized structures in which the three-dimensional structure and differentiated function frequently mimic that of in vivo tissues. This has led to their use in such diverse ap...

Foy, Jh, 1997: The hybrid bermudagrass scene. USGA Green Section record 35(6): 1-4

Miyashita, T.; Baba, M.; Shigeta, S.; Mori, K.; Shinozuka, K., 2003: Synthesis and anti-HIV-1 activity of novel 10-thiaisoalloxazines, a structural analog of C-5 and/or C-6 substituted pyrimidine acyclonucleoside. A series of novel 10-thiaisoalloxazine derivatives bearing an alkoxymethyl or benzyloxymethyl moiety at the N-1 position has been synthesized through the bromination of 1-substituted-5-hydroxyuracils and subsequent condensation with aminobenzeneth...

Fernie, A.R.; Kruger, N.J., 1998: Effect of fructose 2,6-bisphosphate on carbohydrate metabolism in non-photosynthesising tissue. Journal of Experimental Botany 49(SUPPL ): 54, May

Chappellaz J., 2007: Ice core methods; methane studies. This second volume of the Encyclopedia of Quaternary Science continues the ambition to provide comprehensive and authoritative coverage of the subject. Treatment of geography, biology, physics and chemistry of the Earth defines multi-disciplinary...

Villani, G.Q.; Piepoli, M.F., 2003: Biventricular pacing in patients with heart failure and intraventricular conduction delay. In patients with advanced chronic heart failure, characterized by prolonged QRS duration and by decreased cardiac contractility, decreasing dysynchrony by biventricular pacing seems to improve exercise tolerance (6-min walk distance), symptoms (Ne...

Wright L.N.; Dobrenz A.K., 1970: Water use in relation to management of blue panic grass m panicum antidotale m. Journal of Range Management 23(3): 193-196

Menken, S.B.J., 1982: Enzymatic characterisation of nine endoparasite species of small ermine moths (Yponomeutidae). Eight species of Hymenoptera and 1 tachinid that parasitise 8 species of Yponomeuta were investigated in the laboratory in the Netherlands for their allozyme variation at 3-29 loci. The mean heterozygosity of the Hymenoptera was one-third of that...

Torihara, Koji, 1993: A case of acoustic tumor suggested sudden deafness. Jibi Inkoka Tokeibu Geka 65(3): 233-236

Chen S.; Guillory R.J., 1985: The tritiated nadh water exchange reaction of the mitochondrial nadh dehydrogenase. The purified mitochondrial NADH dehydrogenase enzyme has been shown to catalyze a rapid [4B-3H] NADH-H2O exchange reaction. When the enzyme is subjected to a single freeze-thaw cycle there is a complete loss of NADH dehydrogenation without a measu...