geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Protective role of membrane tumour necrosis factor in the host's resistance to mycobacterial infection


, : Protective role of membrane tumour necrosis factor in the host's resistance to mycobacterial infection. Immunology 125(4): 522-534

Tumour necrosis factor- alpha (TNF- alpha ) plays a critical role in the recruitment and activation of mononuclear cells in mycobacterial infection. The role of membrane TNF, in host resistance against Mycobacterium bovis bacille Calmette-Guerin (BCG), was tested in knock-in mice in which the endogenous TNF was replaced by a non-cleavable and regulated allele ( Delta 1-12, TNFtm/tm). While 100% of mice with complete TNF deficiency (TNF-/-) succumbed to infection, 50% of TNFtm/tm mice were able to control M. bovis BCG infection and survived the experimental period. Membrane expressed TNF allowed a substantial recruitment of activated T cells and macrophages with granuloma formation and expression of bactericidal inducible nitric oxide synthase (iNOS). Using virulent Mycobacterium tuberculosis infection we confirm that membrane TNF conferred partial protection. Infection in TNFtm/tm double transgenic mice with TNF-R1 or TNF-R2 suggest protection is mediated through TNF-R2 signalling. Therefore, the data suggest that membrane-expressed TNF plays a critical role in host defence to mycobacterial infection and may partially substitute for soluble TNF.

US$19.90

PMID: 18544042

DOI: 10.1111/j.1365-2567.2008.02865.x


Other references

Hwang, D.F.; Chen, M.Y.; Yoshida, T.; Jeng, S.S., 1993: Toxic effects of linear alkylbenzene sulfonate on the tiger prawn, Penaeus monodon. The toxic effects of linear alkylbenzene sulfonate (LAS) on the larvae and juveniles of tiger prawn Penaeus monodon were tested. The 24-hr LC-50 values of LAS were 0.06, 0.10, and 3.11 ppm for the zoea 2nd substage, mysis 2nd substage (M2), and po...

Deldicque, L.; Theisen, D.; Bertrand, L.; Hespel, P.; Hue, L.; Francaux, M., 2007: Creatine enhances differentiation of myogenic C2C12 cells by activating both p38 and Akt/PKB pathways. In myogenic C(2)C(12) cells, 5 mM creatine increased the incorporation of labeled [(35)S]methionine into sarcoplasmic (+20%, P < 0.05) and myofibrillar proteins (+50%, P < 0.01). Creatine also promoted the fusion of myoblasts assessed by an...

Harris Matthew D.; Chadwick William J., 2000: Predicting the spatial distribution of prehistoric archaeological sites as related to water resources using GIS analysis, in the Lehigh Valley, Pennsylvania. Geographical Information Systems (GIS) spatial analysis related to the distribution of running water, bedrock fractures related to groundwater, and prehistoric archaeological sites is a useful tool in prehistoric occupation site prediction. This G...

Karpov, Vl., 1909: Anfangskursus der Histologie 2-te verb u vermAufl. Unknown

Matthews, K.R.; Kumar, S.J.; O'conner, S.A.; Fox, L.K.; Harmon, R.J.; Pankey, J.W.; Oliver, S.P., 1993: DNA amplification fingerprinting of Staphylococcus aureus. Abstracts of the General Meeting of the American Society for Microbiology 93(0): 525

Mortimer, J.C.; Laohavisit, A.; Macpherson, N.; Webb, A.; Brownlee, C.; Battey, N.H.; Davies, J.M., 2008: Annexins: multifunctional components of growth and adaptation. Plant annexins are ubiquitous, soluble proteins capable of Ca(2+)-dependent and Ca(2+)-independent binding to endomembranes and the plasma membrane. Some members of this multigene family are capable of binding to F-actin, hydrolysing ATP and GTP,...

Anonymous, .: Chemical basis of Alternaria resistance in safflower. The young healthy leaves of safflower cv. NS-133 (resistant to Alternaria infection) had higher contents of phenolic compounds, lower sugar contents and lower activity of polyphenol oxidase than those of the susceptible cv. N 62-8.

Jacobs, L.G., 2008: Thromboembolic disease and antithrombotic agents in the elderly. Preface. Cardiology Clinics 26(2): Xiii-Xxiv

Sloane, P.; Rizzolo, P.; Citron, D.; Olson, P.R.; Cable, T.; Roundtree, W.; White, T.; Norins, M., 1985: Implementation of recommended health maintenance activities in geriatric care. To determine the extent to which health screening and preventive measures are actually documented in family practice, a random sample of 216 charts of established patients over 65 in seven practices was audited. Overall, a high rate of documentati...

Robinson, A.M., 1964: Branched-Chain Fatty Acid Esters As Skin Protective-Therapeutic Agents (Silicone-Free). Journal of the South Carolina Medical Association 60: 381-383