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Salicylate, mefenamate, meclofenamate, and quinine on cochlear potentials

, : Salicylate, mefenamate, meclofenamate, and quinine on cochlear potentials. Otolaryngology--Head and Neck Surgery 102(1): 66-73

The perilymphatic spaces of guinea pig cochleae were perfused with artificial perilymph, with and without drug, at a rate of 2.5 microliters/minute for 10 minutes. The compound action potential of the auditory nerve, cochlear microphonics, and the summating potential evoked by 10 kHz tone bursts of varying intensities were recorded from a wire inserted in the basal turn scala vestibuli. The endocochlear potential was recorded from the scala media. Sodium salicylate (1.25 to 10 mmol/L) reduced the magnitude of the compound action potential evoked by low-sound intensities without affecting the compound action potential evoked by high-sound intensities. Sodium salicylate also reduced cochlear microphonics and had no effect on summating potential. Cochlear perfusions of prostaglandin synthesis inhibitors, mefenamate (200 mumol/L), and meclofenamate (200 mumol/L), had no effect on the cochlear potentials. Quinine (10 to 100 mumol/L) reduced the compound action potential input-output function in a parallel fashion rather than selectively affecting the low-intensity compound action potential. Quinine (100 mumol/L) reduced cochlear microphonics and summating potential. Neither quinine (100 mumol/L) nor salicylate (5 mmol/L) affected endocochlear potential. These results suggest that salicylate-induced hearing loss is not caused by either antagonism of the hair cell transmitter or cyclooxygenase inhibition, nor is it caused by the same mechanism that causes quinine-induced hearing loss.


PMID: 2106119

Other references

Field, H.H., 1899: The International Catalqgue Of Scientific Literature. Science 10(240): 133-143

Wang, X.; Miao, Q.; Song, T.; Yuan, Q.; Gao, J.; Liang, G., 2015: A fluorescent switch for sequentially and selectively sensing copper(II) and L-histidine in vitro and in living cells. Herein, we report the development of a new fluorescent switch for sequential and selective sensing of Cu(2+) and L-histidine (L-His) in vitro and in living cells for the first time. In the absence of metal ions, Ac-SAACQ-Gly-Gly-Gly-Lys (FITC) (1)...

Cheek, D.B., 1962: Importance of recognizing that surgical patients behave as though hypnotized. American Journal of Clinical Hypnosis 4: 227-236

Zhang, W-yan.; Zhang, S-da.; Xiao, T.; Pan, Y-xin.; Wu, L-fei., 2011: Geographical distribution of magnetotactic bacteria. Magnetotactic bacteria (MTB) are widely distributed in aquatic environments. To assess the correlation between their evolutionary relatedness and geographic distribution, we analyzed 239 16S rDNA sequences available in the Genbank, and constructed...

Leĭbson, L.G.; Orbeli, L.A.; Pavlov, I.P., 1990: L. A. Orbeli before the judgement of the Scientific Council on the problems of the physiological theory of I. P. Pavlov. Fiziologicheskii Zhurnal SSSR Imeni I. M. Sechenova 76(12): 1783-1792

Raymond, L.W., 2017: Reassessment of an Asthma Diagnosis. JAMA 317(17): 1801-1801

Moller, C.F.; Olesen, K.P., 1976: Diabetic cystopathy. IV: Micturition cystourethrography compared with urodynamic investigation. Danish Medical Bulletin 23(6): 291-294

Danilevskaia, O.N.; Kurenova, E.V.; Kaverina, E.N., 1988: Localization in the P-element of Drosophila melanogaster of sequences ensuring the autonomic replication of plasmids in yeasts. Two sequences (ARS) capable of maintaining the autonomous replication of plasmids in yeast cells were localized in the right part of Drosophila melanogaster P-element subcloned from the pi 25.1 plasmid. An ARS was found in the DNA region of genome...

Ferguson, J., 1999: The use of narrowband UV-B (tube lamp) in the management of skin disease. Archives of Dermatology 135(5): 589-590

Bartel, S.; Bhakta, N.; Christenson, S., 2017: More Than Meets the Eye: Cigarette Smoke Induces Genomic Changes in the Small Airway Epithelium Independent of Histologic Changes. American Journal of Respiratory and Critical Care Medicine 196(3): 260-262