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Sequential activation of matrix metalloproteinase 9 and transforming growth factor beta in arterial elastocalcinosis

, : Sequential activation of matrix metalloproteinase 9 and transforming growth factor beta in arterial elastocalcinosis. Arteriosclerosis, Thrombosis, and Vascular Biology 28(5): 856-862

Objective-Isolated systolic hypertension is associated with increased elastase activity, vascular calcification, and vascular stiffness. We sought to determine the importance of elastase activity and matrix degradation in the development of elastocalcinosis.Methods and Results-Elastocalcinosis was induced in vivo and ex vivo using warfarin. Hemodynamic parameters, calcium deposition, elastin degradation, transforming growth factor (TGF)-beta signaling, and elastase activity were evaluated at different time points in the in vivo model. Metalloproteinases, serine proteases, and cysteine proteases were blocked to measure their relative implication in elastin degradation. Gradual elastocalcinosis was obtained, and paralleled the elastin degradation pattern. Matrix metalloproteinase (MMP)-9 activity was increased at 5 days of warfarin treatment, whereas TGF-beta signaling was increased at 7 days. Calcification was significantly elevated after 21 days. Blocking metalloproteinases activation with doxycycline and TGF-beta signaling with SB-431542 were able to prevent calcification.Conclusions -Early MMP-9 activation precedes the increase of TGF-beta signaling, and overt vascular elastocalcinosis and stiffness. Modulation of matrix degradation could represent a novel therapeutic avenue to prevent the gradual age-related stiffening of large arteries, leading to isolated systolic hypertension.


PMID: 18292396

DOI: 10.1161/ATVBAHA.107.153056

Other references

Kaul, V.K.; Nigam, S.S.; Banerjee, A.K., 1978: Insecticidal activity of some essential oils. Freshly extracted essential oils from the shade-dried leaves of Artemisia absinthium, A. vestita and A. vulgaris were found to be toxic to house flies in varying degrees. The essential oil of A. vestita showed the maximum toxicity (a 20% solution...

Strich-Harari, D.; Minz, G., 1967: Plant-parasitic nematodes on stone-fruit root-stocks from an experimental orchard. Meloidogyne javanica and M. incognita were the most common plant nematodes found in a survey of an experimental orchard in Acre, Israel. Details of the survey and of the performance of some resistant stocks of Prunus spp. are tabulated.

Pai, I.K.; Hegde, S.N.; Krishnamurthy, N.B., 1990: Genetic effects of Apron 35 SD on the germ cells of the silkworm Bombyx mori L. The genetic effects of Apron 35 SD [metalaxyl] on the male and female germinal cells of Bombyx mori were investigated. The fungicide was injected into the wingbud region of 5-day-old male and female pupae at 50, 100, 200 and 400 p.p.m. The resulti...

Singhi, S.C., 2002: Adrenal insufficiency of critical illness. Indian Pediatrics 39(11): 1011-1016

Khanna, T.; Das, M., 2015: Why gender matters in the solution towards safe sanitation? Reflections from rural India. NlmCategory="UNASSIGNED">While the topic of women and water, sanitation and hygiene is a widely accepted concern among academics and activists, it continues to be an issue in developing countries with serious consequences. Based on a...

Beigel, R.; Hod, H.; Fefer, P.; Asher, E.; Novikov, I.; Shenkman, B.; Savion, N.; Varon, D.; Matetzky, S., 2011: Relation of aspirin failure to clinical outcome and to platelet response to aspirin in patients with acute myocardial infarction. Aspirin failure, defined as occurrence of an acute coronary syndrome despite aspirin use, has been associated with a higher cardiovascular risk profile and worse prognosis. Whether this phenomenon is a manifestation of patient characteristics or f...

Williams Dennis E.; Wilder Dale G., 1971: Gasoline Pollution of a Ground-Water Reservoir; A Case History. Remedial methods, Los Angeles, California.

Healy, E.; Kelly, P.; Clancy, L., 1993: Long term home oxygen; current practices in Ireland. We set out to determine the number of patients being provided with LTOT by the community health services and to review the criteria which are required to be fulfilled before LTOT will be provided by these services. We also wished to determine whet...

Goncalves,G.daS.; Oliveira,; Jaeger,S.M.P.L.; Oliveira,R.L.; Campos,J.O.; Rezende,L.S., 2008: Performance of lambs fed diets with fodder salt composed of xerophilic plants species. This study was conducted to evaluate the use of fodder salt (salt and dicotyledon hay mix) on a daily intake of fodder salt (IFS) and pangola (<i>Digitaria decumbens</i>) hay, and intakes of dry matter (DM), crude protein (CP), neutral...

Hruszka, M., 1991: Yield of field beans in specialized crop rotations in north-east Poland. Vicia faba comprised 50 or 100% of the rotation in a phytometric [microplot?] trial on very good rye complex soil at Pozorty in 1973-80 and 33.5, 50 or 100% of the rotation in a field trial at ezany in 1977-85. In the phytometric trial seed yields...