+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Species-specific properties of the glomerular mesangium

, : Species-specific properties of the glomerular mesangium. Journal of the American Society of Nephrology 3(7): 1342-1350

Mesangial cells play a central role in the physiology and pathophysiology of the glomerulus. To date, most of the in vitro studies have been performed in cultured rat mesangial cells, with only 10% of them performed in human mesangial cells. In this article, the major differences between results obtained with these two types of cultured cells will be reviewed. In rats and in humans, most of the mesangial cells appear to be of smooth muscle origin. In the rat, some of the cultured cells also express a phenotype suggesting a monocyte/macrophage origin. Phagocytosis and synthesis of cytokines or proinflammatory proteins that have been described in cultured rat cells seem mostly linked to this monocyte/macrophage subtype of resident mesangial cells. In humans, macrophages are only detected in pathologic conditions, suggesting that they are not resident but rather infiltrating cells. Mesangial receptors, most notably angiotensin II receptors, are clearly present on mesangial cell membranes and are linked to prostaglandin E2 synthesis and to cell contraction. In humans, spontaneous prostanoid synthesis is low and is increased by the induction of cyclooxygenase by sodium butyrate in the medium. Even so, the amount of prostaglandin E2 synthesized by human mesangial cells is quantitatively low comparatively with that in rats. In rats, accordingly, mesangial cells play a role in the regulation of single-nephron GFR. In humans, angiotensin II also exerts a control on GFR but it is more difficult to demonstrate its contractile effect on human than on rat mesangial cells.


PMID: 8439645

Other references

Mistry V.V.; Kosikowski F.V., 1985: Influence of potassium sorbate and hydrogen peroxide on psychrotrophic bacteria in milk. Potassium sorbate was added to freshly pasteurized, homogenized milk at 0.075, 0.1 and 0.2%. Shelf-like of these milks at C was compared to control milks without sorbate. Bacterial growth was markedly retarded and shelf-life of milk in...

Nargund, R.; Patchett, A.A.; Yang, L., 1998: 4-Heterocyclic peperidines promote release of growth hormone. Official Gazette of the United States Patent & Trademark Office Patents 1211(3): 2928-2929, June 16

Gundavarapu, S.; Wilder, J.A.; Mishra, N.C.; Rir-Sima-Ah, J.; Langley, R.J.; Singh, S.P.; Saeed, A.Imran.; Jaramillo, R.J.; Gott, K.M.; Peña-Philippides, J.Carlos.; Harrod, K.S.; McIntosh, J.Michael.; Buch, S.; Sopori, M.L., 2012: Role of nicotinic receptors and acetylcholine in mucous cell metaplasia, hyperplasia, and airway mucus formation in vitro and in vivo. Airway mucus hypersecretion is a key pathophysiologic feature in a number of lung diseases. Cigarette smoke/nicotine and allergens are strong stimulators of airway mucus; however, the mechanism of mucus modulation is unclear. We sought to characte...

Pech, H.J., 1973: Quantitative angiocardiography of the normal left ventricle. Cor et Vasa 15(2): 101-110

Kim, H.; Yoshida, H.; Hu, X.; Yukawa, H.; Shinkai, S.; Kumagai, S.; Fujiwara, Y.; Yoshida, Y.; Furuna, T.; Sugiura, M.; Ishizaki, T.; Suzuki, T., 2004: Risk factors associated with onset of urinary incontinence in a community-dwelling elderly population: a 4-year follow-up study. To estimate the risk factors associated with onset of urinary incontinence in a rural community-dwelling elderly population. The study area, village N in Akita Prefecture, is a rural community in which a baseline survey of TMIG-LISA (Tokyo Metropo...

Soloveva, M.S., 1964: Some Problems Of Prevention, Clinical Picture And Treatment Of Uterine Rupture Following Cesarean Section. Akusherstvo i Ginekologiia 40: 80-84

Saccabusi, S.; Ena, P.; Satta, G., 2000: Cutaneous leishmaniasis: new atypical clinical course in an endemic area. Two cases of autochthonous cutaneous leishmaniasis with unusual clinical course are described and compared with all affected patients examined over the last twenty years in this endemic region (Sardinia, Italy). In one of the two cases the Leishma...

Dorobantu, L.S.; Bhattacharjee, S.; Foght, J.M.; Gray, M.R., 2009: Analysis of force interactions between AFM tips and hydrophobic bacteria using DLVO theory. Microbial adhesion to surfaces and interfaces is strongly influenced by their structure and physicochemical properties. We used atomic force microscopy (AFM) to measure the forces between chemically functionalized AFM tips and two bacterial specie...

Sauberan, D.P., 2011: Pediatric uveitis. International Ophthalmology Clinics 50(4): 73-85

Zemanek, W., 1975: Delivery of health care in physicians' literary works. Wiadomosci Lekarskie 28(11): 999-1004