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Stereospecific synthesis of - and -baclofen and - and -PCPGABA butyric acid via - and -3-


, : Stereospecific synthesis of - and -baclofen and - and -PCPGABA butyric acid via - and -3-. Chemical & Pharmaceutical Bulletin (Tokyo) 43(8): 1302-1306

(R)- and (S)-Baclofen and (R)- and (S)-PCPGABA (4-amino-2-(4-chlorophenyl)butyric acid) were stereospecifically synthesized via (R)- and (S)-3-(4-chlorophenyl)pyrrolidines, starting from trans-4-hydroxy-L-proline. The syntheses involve two key operations, namely, 1) a stereoselective hydrogenation of dehydroproline derivatives controlled by the C-2 carboxyl function and 2) an effective ruthenium tetroxide oxidation to prepare chiral 3- and 4-(4-chlorophenyl)pyrrolidin-2-ones, which are dehydrated precursors of the target molecules.

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Vimalananda, V.G.; Gupte, G.; Seraj, S.M.; Orlander, J.; Berlowitz, D.; Fincke, B.G.; Simon, S.R., 2015: Electronic consultations (e-consults) to improve access to specialty care: a systematic review and narrative synthesis. We define electronic consultations ("e-consults") as asynchronous, consultative, provider-to-provider communications within a shared electronic health record (EHR) or web-based platform. E-consults are intended to improve access to speci...

Bae, J-Sung.; Jang, K-Ho.; Schuchman, T.R.; Jin, H.Kyung., 2004: Comparative effects of recombinant acid sphingomyelinase administration by different routes in niemann-pick disease mice. An inherited deficiency of acid sphingomyelinase (ASM) activity results in the Type A and B forms of Niemann-Pick disease (NPD). The aim of this study was to evaluate the effects of recombinant human ASM (rhASM) replacement therapy on the mouse mo...

Frost T.F.; Rogers B.G., 1985: Attitudes toward technology and religion among collegiate undergraduates. The relationship between attitudes toward technology and religion among collegiate undergraduates was studied. Attitude measures of religious ideology and technological innovations were administered to 144 education students and 198 business stude...

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Belyakov P.; Kr"stanov K.N.; Shikov K.; Dimitrov E.P.; Stoikov K.; Tsakov K.; Aleksiev G., 1985: Overground biomass and its components in scotch pine plantations. Total biomass quantity and its components in fresh weight and dry matter were assessed in Scots pine plantations aged up to 55 years and of I to IV class quality. Fresh weight of stem wood without the bark represents 73.8% of the total biomass, th...

Wendler, N.L., 1954: Concerning the biogenesis of lysergic acid. A biogenetic pathway to lysergic acid involving condensation of tryptophan with citric acid is proposed.

Feldmann, H., 1953: Treatment of anxiety with apomorphine; application and clinical results. Revue Medicale de la Suisse Romande 73(6): 431-440

Stewart, A.B.E.; Nicholson, K.N.; Fluegeman, R.H., 2011: Geochemical classification and occurrence of drift pumice in New Caledonia. In 2008 and 2010, drift pumice was collected from 42 beaches around the main island of New Caledonia in the S. Pacific. This island is surrounded by a semi-enclosed barrier reef lagoon whose recent designation as a UNESCO World Heritage Site has l...

AKHUTIN.M.N.; OPPEL.V.Andreevich., 1958: V. A. Oppel as a field surgeon. Vestnik Khirurgii Imeni I. I. Grekova 81(9): 44-50

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