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The C. elegans EMAP-like protein, ELP-1 is required for touch sensation and associates with microtubules and adhesion complexes


, : The C. elegans EMAP-like protein, ELP-1 is required for touch sensation and associates with microtubules and adhesion complexes. Bmc Developmental Biology 8: 110-110

Background: The founding member of the EMAP-like protein family is the Echinoderm Microtubule-Associated Protein (EMAP), so-named for its abundance in sea urchin, starfish, and sand dollar eggs. The EMAP-like protein family has five members in mammals (EML1 through EML5) and only one in both Drosophila (ELP-1) and C. elegans (ELP-1). Biochemical studies of sea urchin EMAP and vertebrate EMLs implicate these proteins in the regulation of microtubule stability. So far, however, the physiological function of this protein family remains unknown. Results: We examined the expression pattern of C. elegans ELP-1 by means of transgenic gene expression in living embryos and adults, and by immunolocalization with an ELP-1-specific antibody in fixed tissues. In embryos, ELP-1 is expressed in the hypodermis. In larvae and adults, ELP-1 is expressed in the body wall, spermatheca and vulval muscles, intestine, and hypodermal seam cells. In muscle, ELP-1 is associated with adhesion complexes near the cell surface and is bound to a criss-crossing network of microtubules in the cytoplasm. ELP-1 is also expressed in a subset of mechanoreceptor neurons, including the ray neurons in the male tail, microtubule-rich touch receptor neurons, and the six ciliated IL1 neurons. This restricted localization in the nervous system implies that ELP-1 plays a role in mechanotransmission. Consistent with this idea, decreasing ELP-1 expression decreases sensitivity to gentle touch applied to the body wall. Conclusion: These data imply that ELP-1 may play an important role during the transmission of forces and signals between the body surface and both muscle cells and touch receptor neurons.

US$19.90

PMID: 19014691

DOI: 10.1186/1471-213X-8-110


Other references

Sugiyama, H.; Akiyama, H.; Akiguchi, I.; Kameyama, M.; Takeda, T., 1987: Loss of dendritic spines in hippocampal CA1 pyramidal cells in senescence accelerated mouse (SAM)--a quantitative Golgi study. Rinsho Shinkeigaku 27(7): 841-845

Sabatino, A. di; Cicolani, B.; Miccoli, F.P., 2000: The distribution and ecology of water mites (Acari, Hydrachnidia) in Friuli-Venezia Giulia (Northeastern Italy): an update. Following a first note on the water mites from Friuli Venezia Giulia, an update on the distribution and ecology of the Hydrachnidia from this region is given. From 59 collecting sites, 49 species were identified, 25 of which are new to the fauna o...

Moser, M., 1989: Physiologic changes in the elderly: are they clinically important in the management of hypertension?. Age-related conditions and physiologic changes must be considered when managing the treatment of elderly hypertensives. Decreased aortic distensibility, structural changes in peripheral arteries and arterioles, reduced cardiac output and stroke vo...

Geron, S.M.; Chassler, D., 1995: Advancing the state of the art: establishing guidelines for long-term care case management. This article describes the results of a 15-month project, supported by a grant from The Robert Wood Johnson Foundation, to develop case management practice guidelines for long-term care. Connecticut Community Care, Inc. (CCCI), a nationally recogn...

Clarke, P.N.; Benson, G.M.; Smith, D.R.; Salter, A.; Bell, D.R., 2001: The role of PPARalpha in the mechanism of action of the hypolipidaemic effect of dietary fish oils. Toxicology 168(1): 64, November 1st

Shepard, D., S.; Walsh, J., A.; Kleinau, E.; Stansfield, S.; Bhalotra, S., 1995: Setting priorities for the Children's Vaccine Initiative: A cost-effectiveness approach. To help the Children's Vaccine Initiative (CVI) achieve its goal of new and improved children's vaccines, we developed and applied a cost-effectiveness model to set priorities for vaccine development. The model measures the health benefi...

Anonymous, .: Proceedings of the international meeting on tea information, September 2-5, 1991, Hangzhou, China. Under the joint organization of the Tea Research Institute of the Chinese Academy of Agricultural Sciences and the International Development Research Centre, Canada, an international meeting on tea information was held for the purposes of exchangi...

Guldener, P.H., 1971: The filling technic in endodontics. Schweizerische Monatsschrift für Zahnheilkunde 81(4): 311-327

D.Antoni, E., 1970: Hypoglycemic pancreatic adenomatosis. Clinico-diagnostic and surgical contribution. Annali Italiani di Chirurgia 46(2): 243-258

Vaidya, U.; Wells, M.R., 1993: Nerve crush injury produces phasic variation in dorsal root ganglion S100b protein. Society for Neuroscience Abstracts 19(1-3): 253