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The role of limbic and hypothalamic corticotropin-releasing factor in behavioral responses to stress


, : The role of limbic and hypothalamic corticotropin-releasing factor in behavioral responses to stress. Annals of the New York Academy of Sciences 697: 142-154

CRF in the central nervous system appears to have activating properties on behavior and to coordinate behavioral responses to stress. These behavioral effects of CRF appear to be independent of the pituitary-adrenal axis and can be reversed by a CRF antagonist, alpha-helical CRF9-41. The CRF antagonist reverses not only decreases in behavior associated with stress, but also increases in behavior associated with stress, thus suggesting that the role of CRF is stress dependent and not intrinsic to a given behavioral response. Further, microinjection of alpha-helical CRF9-41 and immunotargeting of CRF neurons in separate brain compartments reveal a link between the anatomical sites that contain CRF and the nature of the behavioral response to stress that can be modified by suppression of endogenous CRF activity therein. Hence, consistent with the dual role of other hypothalamic-releasing factors in integrating hormonal and neural mechanisms by acting both as secretagogues for anterior pituitary hormones and as extrapituitary peptide neurotransmitters, CRF may coordinate coping responses to stress at several bodily levels (Fig. 6). Moreover, dysfunction in such a fundamental homeostatic system may be the key to a variety of pathophysiological conditions including mental disorders.

US$19.90

PMID: 8257007

DOI: 10.1111/j.1749-6632.1993.tb49929.x


Other references

Taniuchi, S.; Tanaka, M.; Kitagawa, H.; Takebayashi, H.; Kiyokawa, M.; Hatano, N.; Honda, M.; Siina, C.; Murakami, A., 2004: A case of transient patchy edema in the outer retina after scleral encircling. A 57-year-old female was referred to us for retinal detachment. She had been seeing flies since 2 months before. Her corrected visual acuity was 0.1 right and 1.2 left. Her intraocular pressure was 7 mmHg right and 12 mmHg left. There were two ret...

Conicella C.; Errico A., 1990: Karyotype variations in pisum sativum ecotype abyssinicum. P. sativum ect. abyssinicum was studied by karyotype and meiotic analyses. Two lines were investigated and resulted to be different from the standard P. sativum karyotype and from each other. Line 2 showed a reciprocal interchange involving chromo...

Henderson, S.; Feiner, S., 2010: Exploring the benefits of augmented reality documentation for maintenance and repair. We explore the development of an experimental augmented reality application that provides benefits to professional mechanics performing maintenance and repair tasks in a field setting. We developed a prototype that supports military mechanics cond...

Margolis, R.M.; Kammen, D.M., 1999: Underinvestment: the energy technology and RandD policy challenge. This Viewpoint examines data on international trends in energy research and development (RandD) funding, patterns of U.S. energy technology patents and RandD funding, and U.S. RandD intensities across selected sectors. The data present a disturbin...

Polykandriotis, E.; Horch, R.E.; Dragu, A.; Bach, A.D.; Kneser, U., 2008: Corrective breast reduction surgery after sternum osteomyelitis and multiple coronary artery bypass surgery. Journal of Plastic, Reconstructive & Aesthetic Surgery 62(11): E525-E527

Markovich, N.Y.; Zarechnaya, S.N., 1992: Data on the distribution of Culex pipiens in the USSR. Maps of distribution of C. pipiens "form" molestus in the (former) USSR were prepared, using literature data and information provided by regional sanitary-epidemiological stations for 1989-90. Although incomplete, the results showed that...

Sandberg, A.A.; Rosenthal, H.E., 1979: Steroid receptors in exocrine glands: the pancreas and prostate. Journal of Steroid Biochemistry 11(1a): 293-299

Biswas N.N.; Tytgat G., 1988: Intraplate seismicity in Alaska. Seismological Research Letters 59(4): 227-233

Karpov, E.; Potapov, N., 1975: Reducing activity of the root surface in corn plants in connection with the differentiation and absorptive capacity. Soviet plant physiology: 22 (2) 298-304

Pieron, H., 1907: De l'autotomie protectrice chez le crabe. Compte Rendu de la Societe de Biologie Paris, 62 906-908