+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

The safety and use of canarypox vectored vaccines

, : The safety and use of canarypox vectored vaccines. Developments in Biological Standardization 84: 165-170

ALVAC recombinants have been administered to humans and animals by parenteral and oral routes without giving signs of replication, systemic dissemination or severe reaction. In principle, it should be impossible for canarypox recombinants to disseminate in the environment as they would not be synthesised in mammalian cells as complete virus. Canarypox vectors have been safe for humans, in whom there has been no evidence of replication, but more work needs to be done to prove absence of replication. Recombinants are immunogenic by the intramuscular and subcutaneous routes. They are also immunogenic when given orally, but the dose required is still under study. Canarypox recombinants effectively prime the immune system for induction of antibodies and CD8 cell-mediated cytotoxicity by protein antigens. Antibody responses are not influenced by prior inoculation of canarypox, of subunit vaccine corresponding to the gene insert, or of vaccinia. Canarypox virus is attenuated for canaries, in which species it is already widely used. In principle, it is non-infectious for humans or other mammals. It may be infectious for other birds.


PMID: 7796950

Other references

Anonymous, 1979: Implementation of United States food aid - Title III. In 1954, the United States Congress enacted PL 480, a statute authorizing a programme of foreign food aid assistance which has since become a major component of US foreign policy. In 1977, Title III of the PL 480 legislation established a "Fo...

Francis, D.E., 1970: Foods and feeding schedule 0-1 year. Community Health 1(5): 250-254

Alekseeva, T.A., 1962: Effect of herpes virus on functional conditions of the sympathetic nervous system. Voprosy Virusologii 7: 211-215

Kravchuk Y.P., 1970: Deep soil studies of oak root systems in old age plantations. Sbornik Rabot Po Lesnomu Khozyaistvu Moldavii Moldavskaya Lesnaya Opytnaya Stantsiya: Ns 129-145

Seki, T.; Hagiwara, H.; Naruse, K.; Kadowaki, M.; Kashiwagi, M.; Demura, H.; Hirose, S.; Naruse, M., 1996: In situ identification of messenger RNA of endothelial type nitric oxide synthase in rat cardiac myocytes. The endothelial type nitric oxide synthase (NOS) termed as NOS-III has been demonstrated in various nonendothelial cells. Although NOS-III was recently found in the cardiac tissues, identification of the cells expressing NOS-III gene in the heart...

Zonneveld, B.J.M.; Iren, F. van, 2000: Flow cytometric analysis of DNA content in Hosta reveals ploidy chimeras. Nuclear DNA content in 84 Hosta cultivars was measured by flow cytometry. The closely related Agave americana was used as an internal standard, calibrated against other reference species. Propidium iodide values were 20% higher than DAPI values, i...

Karthikeya Sharma, T., 2015: Performance and emission characteristics of the thermal barrier coated SI engine by adding argon inert gas to intake mixture. Dilution of the intake air of the SI engine with the inert gases is one of the emission control techniques like exhaust gas recirculation, water injection into combustion chamber and cyclic variability, without scarifying power output and/or therm...

Kuroda, H.; Shibukawa, Y.; Soya, M.; Masamura, A.; Kasahara, M.; Tazaki, M.; Ichinohe, T., 2013: Expression of P2X₁ and P2X₄ receptors in rat trigeminal ganglion neurons. Extracellular ATP, an essential pain mediator, is received by cell-surface ionotropic P2X and/or metabotropic P2Y receptors. Although the contribution of P2X₃ and/or P2X(2/3) receptors toward the pain mechanism is well described in trigeminal ga...

Silang, R.; Regalado, M.; Cheng, T.H.; Wesson, D.E., 2001: Prokinetic agents increase plasma albumin in hypoalbuminemic chronic dialysis patients with delayed gastric emptying. Hypoalbuminemia is a surrogate of malnutrition in patients with end-stage renal disease undergoing chronic dialysis and commonly improves with prescription of adequate nutrition and dialysis. Nevertheless, some patients remain hypoalbuminemic for...

Gripenberg W.S., 1934: Wechselnde Neigung der Erdachse als Grund der Klimaschwankungen in der Erdgeschichte. Changing position of the earth's axis as a reason for climatic change during the history of the earth.