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The treatment of Wilms tumor. Results of the National Wilms Tumor Studies

, : The treatment of Wilms tumor. Results of the National Wilms Tumor Studies. Hematology/Oncology Clinics of North America 9(6): 1267-1274

The study of Wilms tumor has provided a model for the evaluation of the histopathology, prognostic factors, and multimodality therapy regimens in children and adults with rare malignant tumors. The NWTS Group has provided the scientific and administrative framework for the assessment of various treatment schemes in children with renal tumors, a research goal that could not have been realized using the resources available to either a single or a small group of institutions. These studies have yielded higher survival rates while demonstrating that therapy can be individualized according to well-defined risk factors most accurately identified in non-pretreated tumors. Thus, it has been found that treatments associated with significant acute and/or long-term morbidity are not necessary for patients with stage I or II, favorable histology Wilms tumor. Future studies may allow more accurate identification of those patients with stage III and IV/favorable histology Wilms tumor for whom treatment with an anthracycline is not necessary. If successful, this would decrease the size of the group of survivors at risk for cardiac dysfunction, which can follow the administration of even modest cumulative dosages of these agents.


PMID: 8591964

Other references

Mayer, M.; Colon, J., 1971: Chemotherapy by intra-arterial path in cancer of the "head and neck" region. Acta Chirurgica Belgica 70(4): 337-350

Gemmell, A.A.; Murray, H.L., 1932: Two Cases of Simultaneous Intra- and Extra-Uterine Pregnancy, with a Review of the Recorded Cases. Proceedings of the Royal Society of Medicine 25(9): 1385-1386

Fernandes L.A.D.; Porcher C.C.; Silva A.O.M.; Cliff R.A.; Droop G.T.R., 1999: Styles of tectonic reworking of basement in the Dom Feliciano Belt of southern Brazil during the Neoproterozoic. Abstracts - Geological Society of Australia 54: 28-29

Harka A., 1984: The growth of the silurid silurus glanis in the tisza hungary. A study of the growth of the silurid was undertaken on 140 specimens captured between 1976-1981 at the Tisza section near Tiszafured [Hungary] on the basis of the bone of the pectoral fin. The mathematical model of Bertalanffy can be used for the...

Zangle, T.A.; Teitell, M.A.; Reed, J., 2015: Live cell interferometry quantifies dynamics of biomass partitioning during cytokinesis. The equal partitioning of cell mass between daughters is the usual and expected outcome of cytokinesis for self-renewing cells. However, most studies of partitioning during cell division have focused on daughter cell shape symmetry or segregation...

Pasantes Morales H., 1985: Taurine as a modulator effects on the release of neurotransmitters. Boletin De Estudios Medicos Y Biologicos Universidad Nacional Autonoma De Mexico8: 95,

Glesk, I.; Kang, K.; Prucnal, P., 1997: Ultra-fast photonic packet switching with optical control. We report the first demonstration of all-optical multi-bit address recognition at 250 Gb/s using a self-routing scheme. With bit period being only 4 ps, two address bits from each packet header were used for routing. Photonic packets can be remove...

Parvizi, J.; Wickstrom, E.; Zeiger, A.R.; Adams, C.S.; Shapiro, I.M.; Purtill, J.J.; Sharkey, P.F.; Hozack, W.J.; Rothman, R.H.; Hickok, N.J., 2004: Frank Stinchfield Award. Titanium surface with biologic activity against infection. Despite immense improvements, periprosthetic infection continues to compromise the result of otherwise successful joint arthroplasty. There are various limitations in the treatment of periprosthetic infection, the most important of which is the in...

Droste, T., 1999: PPMC difficulties providing hospitals with new opportunities. Executive Solutions for Healthcare Management 2(4): 10-13

Weil Hillman G.; Schell K.; Segal D.M.; Hank J.A.; Sosman J.A.; Sondel P.M., 1991: Activation of human t cells obtained pre interleukin 2 il 2 post interleukin 2 il 2 therapy by anti cd3 monoclonal antibody plus il 2 implications for combined in vivo treatment. The role of activated T cells in the mediation of antitumor responses has been documented in several experimental models. In some of these, interleukin-2 (IL-2) has been used as a means to induce and expand the antitumor effects of the T cells. IL...