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Transmitter release and uptake evoked by the amphibian skin alkaloid, pumiliotoxin-B , in the electrically stimulated mouse vas deferens preparation

, : Transmitter release and uptake evoked by the amphibian skin alkaloid, pumiliotoxin-B , in the electrically stimulated mouse vas deferens preparation. Journal of Autonomic Pharmacology 18(6): 333-342, Dec

1. Upon electrical stimulation three transmitters are known to be released from the adrenergic nerve terminals of the isolated MVD preparation: two motor transmitters (noradrenaline (NA) and ATP) acting synergistically to provoke twitch contraction, and an inhibitory transmitter, the peptide NPY. 2. The frog alkaloid pumiliotoxin-B (PTX-B) displayed two opposite effects on the electrically stimulated MVD: at low concentrations (0.1-0.3 mum) it caused twitch depression, at higher concentrations (0.5-2 mum) there was a potent twitch stimulation. Transmitters and/or receptors involved in the depressive effect could not be clearly identified, although interference with NPY is possible. On the other hand, the potent twitch stimulation caused by PTX-B may be due to exaggerated release of the same transmitters (NA and ATP) involved in twitch stimulation produced by electrical stimulation. 3. Opening by PTX-B of the Na+ channels on the membrane of the adrenergic nerve terminals causes activation of the amine pump facilitating re-uptake of not only endogenous NA but also of exogenous catecholamines.


Other references

Minamoto, S.; Mori, H.; Hatakeyama, M., 1990: Characterization of the heterodimeric complex of human IL-2 receptor ab chains reconstituted in a mouse fibroblast cell line, L929. Journal of Immunology 145: 77-82

Shubik, Martin, 1998: Game theory, complexity, and simplicity part III Critique and prospective. Complexity 3(5): 34-46, May-June

Khokhlova, V.V., 1961: Clinical aspects of tumors with various histological characteristics of the greater hemispheres in children. Zhurnal Nevropatologii i Psikhiatrii Imeni S.S. Korsakova 61: 1005-1011

Hama, Y.; Kosuda, S.; Iwasaki, Y.; Kaji, T.; Kusano, S., 2002: Technetium Tc 99m DTPA galactosyl human serum albumin to measure changes in hepatic functional reserve after transcatheter arterial embolization of the liver. To describe the acute and subacute changes in hepatic functional reserve using technetium Tc 99m diethylenetriaminepentaacetic acid galactosyl human serum albumin (Tc-99m DTPA GSA) in patients with hepatocellular carcinoma and liver cirrhosis who...

Vega P.; Rojas E., 1967: Membrane conductance in frog sartorius muscle in the presence of a single cation abstract potassium ion. Archivos de Biologia y Medicina Experimentales 4(1/2): 232

Ekanem, E.; Otti, B., 1997: Total plate count and coliform levels in Nigerian periwinkles from fresh and brackish water. Three species of freshly harvested Nigerian periwinkles — Tympanotonus fuscatus T. fuscatus var radula (both of brackish water habitat) and Pachymelinia bryonensis (a fresh water species) — were evaluated for bacteriological quality using aero...

Iivanainen, A.; Kortesmaa, J.; Sahlberg, C.; Morita, T.; Bergmann, U.; Thesleff, I.; Tryggvason, K., 1997: Primary structure, developmental expression, and immunolocalization of the murine laminin alpha4 chain. The complete primary structure of the mouse laminin alpha4 chain was derived from cDNA clones. The translation product contains a 24-residue signal peptide preceding the mature alpha4 chain of 1,792 residues. Northern analysis on whole mouse embry...

Schimming, I.; Mann, H., 1984: Historical limitations on the quality of medical responsibility for the preservation of human life and care of the dying. Zeitschrift für Arztliche Fortbildung 78(16): 693-694

Vu, V.; Singer, S.T.; Mignacca, R.; Morel, P.; Vichinsky, E., 1999: Alloimmunization and autoimmunization in predominantly Asian transfusion dependent thalassemia patients. Blood 94(10 SUPPL 1 PART 1): 422a-423a, Nov 15

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