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Vascularity change and tumor response to neoadjuvant chemotherapy for advanced breast cancer

, : Vascularity change and tumor response to neoadjuvant chemotherapy for advanced breast cancer. Ultrasound in Medicine & Biology 34(6): 857-866

For advanced breast cancer with severe local disease (ABC) (stage HUM, neoadjuvant chemotherapy improves local control and surgical outcome. However, about similar to 20 to 30% of advanced cancers show either no or poor response to chemotherapy. To prevent unnecessary treatment, a capability of predicting clinical response to neoadjuvant chemotherapy of ABC is highly desirable. Vascularity index (VI) of breast cancers was derived from the quantification results in 30 ABC patients by using power Doppler sonography. Power Doppler sonography evaluation was performed every one to two weeks during chemotherapy. The overall response rate for 30 advanced patients tested was 70%, when 50% or more reduction in tumor size was the objective clinical response. Chemotherapy response was unrelated to the original tumor size (p = 0.563) or chemotherapy agents used (p = 0.657). The median VI for all 30 patients was 4.99%. The response rates for hypervascular tumors vs. hypovascular tumors, based on initial median value, were 86.7% and 53.3%, respectively (p = 0.109). The average VIs in responders and nonresponders were 7.67 +/- 4.77% and 4.01 +/- 3.82% (p = 0.052). There was a tendency for responders who have a relatively high initial vascularity. The VI change in responder group shows a pattern of initial increasing in vascularity followed by decreasing in vascularity. All patients (17/17) with a VI increment of > 5% during chemotherapy had good chemotherapy response, whereas in patients with a VI increment of < 5%, the response rate was 30.8% (4/13) (p < 0.001). For patients with a peak VI of > 10% during chemotherapy, the response rate was 94.1% (16/17). However, in patients with a peak VI of < 10%, the response rate was 38.5% (5/13) (p = 0.001). This prediction was made mostly within one month (25.47 +/- 12.96 d for VI increments > 5% and 25.44 +/- 12.41 d for VI increased to > 10%). In the meantime, the differences in size reduction shown in B-mode sonography were insignificant between responders and nonresponders (patient group with VI increment > 5%,p = 0.308; patient group with peak VI > 10%,p = 0.396). In conclusion, we propose that VI as determined by using power Doppler sonography is a good and inexpensive clinical tool for monitoring vascularity changes during neoadjuvant chemotherapy in ABC patients. Two parameters-VI increment > 5% and peak VI > 10%-are potential early predictors for good responses to neoadjuvant chemotherapy within one month in patients with ABC. (E-mail: (c) 2008 Published by Elsevier Inc. on behalf of the World Federation for Ultrasound in Medicine & Biology.


PMID: 18374468

DOI: 10.1016/j.ultrasmedbio.2007.11.011

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Lossos, I.S.; Okon, E.; Bogomolski-Yahalom, V.; Ron, N.; Polliack, A., 1997: Sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease): Report of a patient with isolated renotesticular involvement after cure of non-Hodgkin's lymphoma. Sinus histiocytosis with massive lymphadenopathy (SHML) - Rosai-Dorfman disease - is a rare but well-defined benign histiocytic proliferative disorder. We report an unusual patient. cured of non-Hodgkin's lymphoma, who presented 12 years late...

Mackinnon, S., 1997: Donor leukocyte infusions. Donor leukocyte therapy has resulted in a remission rate in excess of 70% in patients with relapse of chronic myeloid leukaemia (CML) following allogeneic bone marrow transplantation (BMT). Induction of remission with donor leukocyte infusions has...

Sidner, R.; Davis, R., 1988: Records of nectar-feeding bats in Arizona. Southwestern Naturalist, 334: 493-495

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Chen, W.; Jin, W.; Wahl, S.M., 1998: Engagement of cytotoxic T lymphocyte-associated antigen 4 induces transforming growth factor beta production by murine CD4+ T cells. Evidence indicates that cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) may negatively regulate T cell activation, but the basis for the inhibitory effect remains unknown. We report here that cross-linking of CTLA-4 induces transforming growt...

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Rudler, J.C.; Angles, C.; Megevand, R., 1963: Postoperative Mortality After Resection In Cancer Of The Middle Segment Of The Thoracic Esophagus. Improvement Of Results By Use Of The Engstroem Respirator During Anesthesia. Thoraxchirurgie und Vaskulare Chirurgie 11: 95-99

Grujicic, G., 1971: Stem nematode (Ditylenchus dipsaci Kuhn) with reference to host plants in Serbia. Zastita Bilja(114): 159-171