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Visual deficits related to dopamine deficiency in experimental animals and Parkinson's disease patients

, : Visual deficits related to dopamine deficiency in experimental animals and Parkinson's disease patients. Trends in Neurosciences 13(7): 296-302

In patients affected by Parkinson's disease, and in the monkey model of this disease, visual defects have been shown using psychophysical and electrophysiological measures of spatial and temporal contrast sensitivity. These studies imply an essential role for dopamine in primate vision. There is electrophysiological and neurochemical evidence to suggest that at least part of the problem is impaired retinal processing caused by systemic dopaminergic deficiency. Some of the deficits that have been demonstrated, consistent with physiological studies, suggest that center-surround interaction of neurons may suffer as a consequence of dopaminergic deficiency. The role of the regulation of retinal dopamine (D1 and D2) receptors in primate vision and of the balance of these receptors in presynaptic dopaminergic deficiency is not yet determined. Using sinusoidal grating stimuli in cognitively loaded tasks may increase understanding of the behavioral consequences of visual deficits seen in dopamine deficiency syndromes.


PMID: 1695407

DOI: 10.1016/0166-2236(90)90113-o

Other references

Cosyns J P.; Pirson Y.; Squifflet J P.; Alexandre G.P.J.; D.S.rihou C.V.; Pinn V.W.; Sweet S.J.; Shapiro K.S.; Cho S.; Harrington J.T., 1982: De novo membranous nephropathy in human renal allo grafts report of 9 patients. Nine new patients with de novo membranous nephropathy (MN) are reported. The onset of MN, as defined by onset of nephrotic-range proteinuria, ranged from 11-30 mo. after transplantation. Of the 9 patients, 5 returned to hemodialysis within 4-26 mo...

Bregetzer, J., 1976: Towards a health education policy: the anti-tobacco campaign. Revue de L'infirmiere 26(9): 814-815

Horne, DJ., 1986: On Aurila woutersi Horne sp. nov. Stereo-Atlas of Ostracod Shells, 131: 33-38

Fung, J.W.; Lam, K.S., 1995: Neurofibromatosis and insulinoma. A 45-year-old man with neurofibromatosis presented with recurrent seizures due to hypoglycaemia caused by an insulinoma. The attacks were abolished after the successful removal of the insulinoma. This probably represents another example of the ass...

Nowak A.J.; Erenberg A., 1983: Palatal and alveolar ridge grooves in oro tracheal intubated neo nates. Journal of Dental Research 62(SPEC ISSUE): 237

Heim, T.; Szelenyi, Z., 1965: Effect of semistarvation on the thermoregulation of the developing organism. ACTA PHYSIOL ACAD SCI HUNG 26(Suppl ): 46

Lloyd, R.B.; Chandra, S.N., 1930: A Case of Highly Abnormal Blood Group Associated with Auto-Agglutination in the Cold. Indian Medical Gazette 65(1): 1-4

Boldyrev, A.A., 2001: Functional interaction between various glutamate receptors. The interaction of glutamate with various receptors in glutamatergic neurons and functional interaction between glutamate receptors are reviewed. It is hypothesized that metabotropic receptors perform defensive functions in the brain by protecting...

Bowen, J.F.; Beech, F.W., 1964: The distribution of yeasts on cider apples. The distribution of yeasts on cider apples was studied in orchards of the cider-making counties of England. The typical fruit flora consisted almost entirely of small numbers of weakly fermentative nonsporing yeasts. No species were completely cha...

Noyes, C.D.; Noyes, C.D., 1993: Address of President Clara D. Noyes. Proceedings of the twenty-first annual convention of the NLNE, 1915, San Francisco, California. Nln Publications: 120-123