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Advances in classification and therapy of indolent B-cell malignancies

, : Advances in classification and therapy of indolent B-cell malignancies. Seminars in Oncology 29(1 Suppl 2): 98-104

Advances in our understanding of normal B-cell differentiation have allowed for improved classification and therapy of B-cell malignancies. B-cell neoplastic diseases may be classified more accurately according to the differentiation stages of presumed normal B-cell counterparts. These advances have challenged the notion that chronic lymphocytic leukemia represents a malignancy of naive CD5 B cells. Analyses of immunoglobulin genes and gene expression patterns through microarray have defined at least two types of chronic lymphocytic leukemia that differ in their tendency toward disease progression. Nevertheless, these types still share more in common than they do with other lymphoid malignancies, and both may be derived from memory-type B cells. Advances in immune therapy are revolutionizing the approach to therapy. B-cell surface differentiation antigens constitute tissue-specific targets for passive immune therapy. Since the US Food and Drug Administration approval of rituximab (Rituxan; Genentech, Inc, South San Francisco, CA, and IDEC Pharmaceuticals, San Diego, CA) for use in the treatment of follicular lymphoma, monoclonal antibody therapy is being considered for all types of B-cell malignancies. The ability to transform leukemia and lymphoma B cells into effective antigen-presenting cells through CD40 ligation allows for autologous immune recognition of neoplastic cells. Together, active and passive immune approaches have potential for effective treatment of patients with these diseases.


PMID: 11842396

DOI: 10.1053/sonc.2002.30146

Other references

Salajka E., 1969: Plasma mono amine oxidase during the 1st pregnancy of the cow. Documenta Veterinaria: 7-214

Young, M., 1981: Body image of and contraceptive use by college females. This study investigates the role of body image and use of contraception among 231 female freshmen. The subjects completed Secord and Jourard's body-cathexis scale, and a questionnaire concerning sexual behavior and use of contraceptives. Only...

Tremayne, W.H., 2005: Dollars & sense of the health care industry. New Jersey Medicine 95(5): 71-73

McHarg Ian L., 1974: The place of nature in the city of man. 2: 30-41 1974

Böhmer, M.R.; Chlon, C.H.T.; Raju, B.I.; Chin, C.T.; Shevchenko, T.; Klibanov, A.L., 2011: Focused ultrasound and microbubbles for enhanced extravasation. The permeability of blood vessels for albumin can be altered by using ultrasound and polymer or lipid-shelled microbubbles. The region in which the microbubbles were destroyed with focused ultrasound was quantified in gel phantoms as a function of...

Feller, I.; Hill, C.C., 1963: Surgical Wire Welding. A technique for surgical wire welding has been devised, tested in animals, and successfully applied clinically.

Ekhart, C.; Rodenhuis, S.; Schellens, J.H.M.; Beijnen, J.H.; Huitema, A.D.R., 2008: Carboplatin dosing in overweight and obese patients with normal renal function, does weight matter?. The purpose of this study was to determine the potential utility of alternative weight descriptors in the Cockcroft-Gault equation to more accurately predict carboplatin clearance in underweight, normal weight, overweight and obese patients. Clear...

Heins, T.J.; Yelland, J.H., 1981: Validity studies on the Ryle Marital Patterns Test. The case for a questionnaire for assessing marital interaction has been enhanced by recent research showing that patterns of marital interaction can indicate prognosis in schizophrenia, alcoholism, neurotic illnesses and depression. This paper rev...

Dasgupta, G.; Schwartz, M.; Slone, V.; Sender, L.S., 2001: Dendritic cell based immunotherapy for prevention of relapse in neuroblastoma patients. Proceedings of the American Association for Cancer Research Annual Meeting 42: 185, March

Stroganova, A.S., 1958: On the ecology of the Caucasian squirrel Sciurus Tenes anomalus Guld, 1792. Trudy Zoologicheskogo Instituta, 25: 304-320