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Age dependent hypoxic ischemic changes in t1 and t2 relaxation times and their correlation with water content in rat brain


, : Age dependent hypoxic ischemic changes in t1 and t2 relaxation times and their correlation with water content in rat brain. Society for Neuroscience Abstract Viewer & Itinerary Planner : Abstract No 404 9

Introduction: We have observed age-dependent cerebral hypoxic-ischemic changes in T2 relaxation that did not correlate well with alterations in water content. We now hypothesize that T1-weighted magnetic resonance imaging will be superior to T2-weighted imaging in detecting age-dependent ischemic changes in total brain water. Methods: The right carotid artery was isolated surgically (sham control) or occluded with subsequent exposure to 8% oxygen for either 1.5 hrs or 30 min. in one-week old and four-week old rats, respectively (n=20 each). T1 and T2 maps were acquired before, during and for 1 and 24 hrs after hypoxia-ischemia (HI) using a 9.4T magnetic resonance system. Water content was assessed as wet/dry weights in subgroups of these animals. Results: In the control group, both T1 and T2 decreased with increasing age, corresponding to a decrease in water content. In 1-week-old rats, T1, T2 and water content increased during HI. Within 1h after HI, the increases in T2 were partially restored but T1 and water content remained elevated and these increases remained at 24h after HI. In 4-week-old rats, T1 and water content increased during HI followed by a partial recovery at 1h after HI, and increased again at 24h after HI. However, in 4 week-olds, T2 was not increased until 24h after HI. Conclusions: Hypoxic-ischemic changes in T1 occurred earlier than those in T2 in 4-week old animals and T1 had a better correlation with total brain water compared to T2, irrespective of age. This suggests that T1 imaging is more sensitive than T2 imaging to detect brain edema induced by HI.

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