+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Age dependent hypoxic ischemic changes in t1 and t2 relaxation times and their correlation with water content in rat brain

, : Age dependent hypoxic ischemic changes in t1 and t2 relaxation times and their correlation with water content in rat brain. Society for Neuroscience Abstract Viewer & Itinerary Planner : Abstract No 404 9

Introduction: We have observed age-dependent cerebral hypoxic-ischemic changes in T2 relaxation that did not correlate well with alterations in water content. We now hypothesize that T1-weighted magnetic resonance imaging will be superior to T2-weighted imaging in detecting age-dependent ischemic changes in total brain water. Methods: The right carotid artery was isolated surgically (sham control) or occluded with subsequent exposure to 8% oxygen for either 1.5 hrs or 30 min. in one-week old and four-week old rats, respectively (n=20 each). T1 and T2 maps were acquired before, during and for 1 and 24 hrs after hypoxia-ischemia (HI) using a 9.4T magnetic resonance system. Water content was assessed as wet/dry weights in subgroups of these animals. Results: In the control group, both T1 and T2 decreased with increasing age, corresponding to a decrease in water content. In 1-week-old rats, T1, T2 and water content increased during HI. Within 1h after HI, the increases in T2 were partially restored but T1 and water content remained elevated and these increases remained at 24h after HI. In 4-week-old rats, T1 and water content increased during HI followed by a partial recovery at 1h after HI, and increased again at 24h after HI. However, in 4 week-olds, T2 was not increased until 24h after HI. Conclusions: Hypoxic-ischemic changes in T1 occurred earlier than those in T2 in 4-week old animals and T1 had a better correlation with total brain water compared to T2, irrespective of age. This suggests that T1 imaging is more sensitive than T2 imaging to detect brain edema induced by HI.


Other references

Chang, C.Y.; Thomas, J.P., 2008: Adult-onset iatrogenic tracheomalacia. Ear, Nose, & Throat Journal 87(6): 312-314

Kollatsch, D., 1992: Decentralised private wastewater treatment in rural areas. In Lower Saxony, the second largest Federal State in Germany, almost 6.7 million of the 7.4 million inhabitants are connected to sewerage systems and thus to central, biological sewage treatment plants; 950 000 persons currently still discharge to...

Friedman, J.W.; Ingle, J.I., 1973: New Zealand dental nurse report. Journal - California Dental Association 1(1): 7-8

Tikhomirova, N.I.; Khvatov, V.B., 1977: Fibrinolytic properties of "peritoneal" blood used for reinfusion in gynecologic practice. Problemy Gematologii i Perelivaniia Krovi: 38-42

Cherevko A.S.; Syso A.I.; Polyakova G.E. (Polyakova G.Y.), 2000: Simultaneous determination of micro- and macroelements in plant ash by atomic emission spectroscopy using an arc argon two-jet plasmatron. A procedure has been developed for the multielemental analysis of plant ash by atomic emission spectroscopy using an are argon two-jet plasmatron as the source of spectrum excitation. The conditions for the excitation and registration of spectra b...

Christophersen, J.; Baadsgaard, O.; Christiansen, J., 1986: IgE antibodies to Staphylococcus aureus. Archives of Dermatology 122(9): 971-971

van de Walle, M.; Fass, R.; Shiloach, J., 1990: Production of cholera toxin subunit B by a mutant strain of Vibrio cholerae. The B subunit (CTB) of cholera toxin (CT) can be used as a carrier protein for conjugate vaccines designed to elicit antipolysaccharide antibodies. A defined medium, AGM4, was designed to grow a high-producing mutant of Vibrio cholerae expressing...

Grey Kathleen; Gee R.D.nnis, 1986: Stromatolites in the Precambrian Glengarry Sub-basin, Nabberu Province, Western Australia. Pages 127-128 1986

Anonymous, 1951: LEEDS tuberculosis scheme. Lancet 1(6669): 1364-1366

Minkoff, H.L.; Sierra, M.F.; Pringle, G.F.; Schwarz, R.H., 1982: Vaginal colonization with Group B beta-hemolytic streptococcus as a risk factor for post-cesarean section febrile morbidity. Vaginal colonization of mothers with Group B beta-hemolytic streptococcus (GBS) has been recognized as a risk factor for neonatal morbidity. The relationship of GBS colonization to risks for the mother who undergoes cesarean section has not been d...