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Allorecognition of the recipient after hematopoietic transplantation

, : Allorecognition of the recipient after hematopoietic transplantation. Bulletin du Cancer 90(8-9): 706-710

Donor allorecognition of the recipient after hematopoietic transplantation can result in graft-versus-host disease, a potent graft-vs-leukemia effect as well as a graft facilitation effect. Danger signals, host Ag-presenting cells and minor histocompatibility Ag have recently emerged as major determinants of such an alloreactivity. A better understanding of the involved immune mechanisms, the development of novel immunomonitoring tools and cell engineering approaches should result in a significantly increased therapeutic index of allogeneic alloreactivity.


PMID: 14609760

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