+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

An approach to -pancratistatin from D-glucose A conformational lock solves a stereochemical problem

, : An approach to -pancratistatin from D-glucose A conformational lock solves a stereochemical problem. Tetrahedron Letters 40(14): 2691-2694, April 2

In previous work we discovered that reductive Pd-mediated aryl-enone cyclization of an advanced intermediate resulted in epimerization of a critical stereocenter. Analysis of conformational and steric effects could rationalize the result. Based on that analysis it was anticipated that a conformational lock could suppress the undesired epimerization. Results reported herein confirm that expectation.


DOI: 10.1016/s0040-4039(99)00334-2

Other references

Palmen, J.A., 1908: Vara flyktfaglar.. Unknown

Li, M.; Lindblad, J.L.; Perez, E.; Bergmann, A.; Fan, Y., 2016: Autophagy-independent function of Atg1 for apoptosis-induced compensatory proliferation. ATG1 belongs to the Uncoordinated-51-like kinase protein family. Members of this family are best characterized for roles in macroautophagy and neuronal development. Apoptosis-induced proliferation (AiP) is a caspase-directed and JNK-dependent proc...

Silberberg, J.S.; Bowman, L.K.; Murton, F.J.; Cranney, G.B.; Walsh, W.F.; Giles, R.W., 1989: Left ventricular volumes in moderate alcohol users: a study from the workplace. We measured resting and exercise left ventricular volumes by a count-based, nongeometric radionuclide method in 23 healthy volunteers grouped according to reported average daily alcohol consumption: 0-20 g (Gp A), 21-50 g (Gp B) and greater than 5...

Anonymous, 2016: Self-Assessment. Dermatitis 27(6): 315-316

Calzavara, F.; Manganiello, A.; Tassini, T., 1968: Current therapeutic trends in Hodgkin's disease (case reports). Il Friuli Medico: Suppl 6:1167+-Suppl 6:1167+

Descotes, J.; Chignier, E.; Barral, X., 1977: Aneurysmal and pseudo-aneurysmal forms of carotid artery dysplasia in their extracranial portion. Revue D'oto-Neuro-Ophtalmologie 49(4): 301-303

Quinn Paul; Anderton Steve, 1998: Nesting localized models and data within catchment models and data. Annales Geophysicae (1988): uppl. 2; Pages 500. 1998.

Ehret, R.; Schab, J.; Weiler, E., W., 1994: Lipoxygenases in Bryonia dioica Jacq. Tendrils and cell cultures. Lipoxygenases in differentiated and undifferentiated tissues of Bryonia dioica were characterized. The enzymes from tendrils and tissue cultures were purified. Leaf, stem and root tissue as well as cell cultures predominantly contain enzymes with...

Gibori, G.; Chen, Y.D.; Khan, I.; Azhar, S.; Reaven, G.M., 1984: Regulation of luteal cell lipoprotein receptors, sterol contents, and steroidogenesis by estradiol in the pregnant rat. Although estradiol has been found to possess receptors in the luteal cell and to stimulate progesterone synthesis, its mechanism of action in the corpus luteum remains completely unknown. To determine whether estradiol modulates cellular uptake of...

Touchan Ramzi; Meko David; Hughes Malcolm, 1999: A 396-year reconstruction of precipitation in southern Jordan. Water resources are the lifeblood of the Near East region. Careful planning and management of water resources in dry land regions requires information on the likelihood of extreme events, especially prolonged drought. It is essential to understand...