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An approach to -pancratistatin from D-glucose A conformational lock solves a stereochemical problem


, : An approach to -pancratistatin from D-glucose A conformational lock solves a stereochemical problem. Tetrahedron Letters 40(14): 2691-2694, April 2

In previous work we discovered that reductive Pd-mediated aryl-enone cyclization of an advanced intermediate resulted in epimerization of a critical stereocenter. Analysis of conformational and steric effects could rationalize the result. Based on that analysis it was anticipated that a conformational lock could suppress the undesired epimerization. Results reported herein confirm that expectation.

US$19.90

DOI: 10.1016/s0040-4039(99)00334-2


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