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Antiangiogenic effect of diet polyphenols


, : Antiangiogenic effect of diet polyphenols. FASEB Journal 17(4-5): Abstract No 867 10, March

Epidemiological data show that diet polyphenols exert a protective action on gastrointestinal cancers, but the mechanisms are still debated. In particular it is not known whether the action is due to mixtures of different polyphenols or single components or products of their metabolism.By using endothelial cells form bovine microvessels (CVEC) and the in vivo rabbit cornea model, we have evaluated the activity of different families of polyphenols (coumaric acids, catechins, quercetins, cyanidins). We have studied both single components, isolated and purified for vegetal products, and substances derived form their hepatic and intestinal metabolism.Endothelial cell migration and proliferation promoted by vascular endothelial growth factor (VEGF) were abolished by polyphenols derivatives, being low (nanomolar) concentrations effective. Polyphenols neovascular growth induced by VEGF We can thus hypothesise that diet polyphenols exert a protective effect against tumor growth and spreading through inhibition of angiogenesis. These compounds can be regarded as a source of new antiangiogenic/antitumor drugs.

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