+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Antiangiogenic effect of diet polyphenols

, : Antiangiogenic effect of diet polyphenols. FASEB Journal 17(4-5): Abstract No 867 10, March

Epidemiological data show that diet polyphenols exert a protective action on gastrointestinal cancers, but the mechanisms are still debated. In particular it is not known whether the action is due to mixtures of different polyphenols or single components or products of their metabolism.By using endothelial cells form bovine microvessels (CVEC) and the in vivo rabbit cornea model, we have evaluated the activity of different families of polyphenols (coumaric acids, catechins, quercetins, cyanidins). We have studied both single components, isolated and purified for vegetal products, and substances derived form their hepatic and intestinal metabolism.Endothelial cell migration and proliferation promoted by vascular endothelial growth factor (VEGF) were abolished by polyphenols derivatives, being low (nanomolar) concentrations effective. Polyphenols neovascular growth induced by VEGF We can thus hypothesise that diet polyphenols exert a protective effect against tumor growth and spreading through inhibition of angiogenesis. These compounds can be regarded as a source of new antiangiogenic/antitumor drugs.


Other references

Gao, H.; Kong, J.; Li, Z.; Xiao, G.; Meng, X., 2011: Quantitative analysis of temperature, salinity and pH on WSSV proliferation in Chinese shrimp Fenneropenaeus chinensis by real-time PCR. White spot syndrome virus (WSSV) is the most serious disease threatening the shrimp farming. Previous studies have elucidated the relationships between WSSV outbreak and environmental factors such as temperature, salinity and pH. But, these studie...

Erickson K.R.; Kelly M.J.; Laxer K.D.; Rosenbaum T.J.; Ronnekleiv O.K., 1986: Combined electrophysiological and immunocytochemical studies of human hippocampus from patients with temporal lobe epilepsy. Society for Neuroscience Abstracts 12(2): 1255

Schmeling, A.; Correns, A.; Wirth, I., 2006: The case of a corpse found in a fox's den--forensic and criminological aspects. Whenever foul play is suspected in a death, the forensic pathologist is required to examine the corpse where it is found. In the case described here, the unusual location of the corpse initially led investigators to suspect a crime was involved. A...

Tanaka, T.; Saito, H.; Matsuki, N., 1993: Endogenous nitric oxide inhibits NMDA- and kainate- responses by a negative feedback system in rat hippocampal neurons. Involvement of endogenous nitric oxide (NO) on glutamate receptor-mediated response was investigated in neuronal cells cultured from embryonic rat hippocampus. L-NG-Nitroarginine (NOARG), a NO synthase inhibitor, augmented NMDA- and kainate-induce...

Anonymous, 1991: Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 14-1991. A 17-year-old boy with a left posterior intrathoracic mass. New England Journal of Medicine 324(14): 980-986

Raab, E.; Carranza, J.; Heaney, J.; Rickels, K., 1966: Deanol (paxanol) in anxiety. (A contribution to the methodology of cross-over studies). Diseases of the Nervous System 27(8): 544-546

Porterfield, Rl, 1980: Successful application of research findings in managing champion timberlands. Forest products journal 30(10): 16-20

Hofer, S.E.; Schwandt, A.; Holl, R.W., 2016: Standardized Documentation in Pediatric Diabetology: Experience From Austria and Germany. This article gives a short summary of standardized documentation for pediatric diabetology from a European perspective. The approach chosen by the Austrian/German DPV (Diabetes Patienten Verlaufsdokumentation) group is detailed. The electronic hea...

Norsk, P., 2007: How can human beings perform in the outer space? Exercise in space. Ugeskrift for Laeger 168(51): 4516-4516

Brandenberger; Kaiser; Shellard; Turok, 1987: Peculiar velocities from cosmic strings. Physical Review. D, Particles and Fields 36(2): 335-345