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Apolipoprotein-E allele-specific regulation of nitric oxide production


, : Apolipoprotein-E allele-specific regulation of nitric oxide production. Annals of the New York Academy of Sciences 962: 212-225

Cognitive decline and dementia are key features of Alzheimer's disease (AD) that result from failure of neuronal function. Affected neurons demonstrate indices of nitrosative stress resulting from changes in nitric oxide (NO) mediated redox balance. Neurofibrillary tangles, a characteristic neuropathologic feature of AD, and dysfunctional neurons frequently display 3-nitrotyrosine or other markers of nitrosative stress and immunoreactive nitric oxide synthase (NOS), suggesting that NOS-containing neurons are affected in AD. Our previous studies showed that apolipoprotein E treatment of macrophages increased NO production. Using transgenic mouse models expressing human apoE2, apoE3, or apoE4 protein isoforms and no mouse apoE, we now report an isoform specific difference in microglial NO production. Mice expressing the apoE4 protein isoform have a greater NO production than mice expressing the apoE3 protein isoform. The supply of arginine, the sole substrate for NOS, is dependent on cationic amino acid transporters (CATs) that also demonstrate a similar pattern of apoE isoform dependency. Although arginine transport is greater in APOE4 microglia, this effect is not limited to tissue macrophages. Cortical neurons in primary culture from APOE4 transgenic mice exhibit a similar increase in arginine uptake over neurons cultured from APOE3 mice. The inappropriate levels of arginine transport and of NO in the presence of the APOE4 compared to the APOE3 gene and its products are likely to have significant impact in the CNS.

US$19.90

PMID: 12076977

DOI: 10.1111/j.1749-6632.2002.tb04070.x


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Conde, F.J.; Afonso, A.M.; González, V.; Ayala, J.H., 2006: Optimization of an analytical methodology for the determination of alkyl- and methoxy-phenolic compounds by HS-SPME in biomass smoke. A sampling and analysis method for the determination of 21 phenolic compounds in smoke samples from biomass combustion has been developed. The smoke is used to make smoked foods, following an artisanal procedure used in some parts of the Canary Is...

Tumbleson, M.E.; Kommedahl, T., 1962: Factors affecting dormancy in tubers of Cyperus esculentus. Upon investigation of the effect of low temperature on tuber germination and shoot production it was found that storing tubers at 3[degree] C for 2 weeks did not increase the percentage germination of tubers; however, there was a 100% increase in...

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Schreiber, M.J.; Holmes, E.C.; Ong, S.Hoe.; Soh, H.S.H.; Liu, W.; Tanner, L.; Aw, P.P.K.; Tan, H.Cheng.; Ng, L.Ching.; Leo, Y.Sin.; Low, J.G.H.; Ong, A.; Ooi, E.Eong.; Vasudevan, S.G.; Hibberd, M.L., 2009: Genomic epidemiology of a dengue virus epidemic in urban Singapore. Dengue is one of the most important emerging diseases of humans, with no preventative vaccines or antiviral cures available at present. Although one-third of the world's population live at risk of infection, little is known about the pattern...

Haraguchi, S.; Kurakata, S.; Matsuo, T.; Yoshida, T.O., 1985: Strain differences in the antitumor activity of an immunopotentiator, Nocardia rubra cell-wall skeleton, in B10 congenic and recombinant mice. An immunogenetic evaluation of the antitumor activity of the immunopotentiator Nocardia rubra cell-wall skeleton (N. rubra-CWS) has been performed using non-virus-producing tumors induced by the Schmidt-Ruppin strain of Rous sarcoma virus (RSV) in...

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Hantz D.; Laversanne J.; Paquette Y., 1990: Slide along a fault in an open-pit coal mine. Reunion Annuelle des Sciences de la Terre: ages 65. 1990.

Krishnamurthy, P.; Romagni, P.; Torvik, S.; Gold, P.W.; Charney, D.S.; Detera-Wadleigh, S.; Cizza, G., 2008: Glucocorticoid receptor gene polymorphisms in premenopausal women with major depression. Glucocorticoid receptor gene polymorphisms are associated with glucocorticoid hypersensitivity and visceral obesity. Perturbations in HPA axis sensitivity to glucocorticoids implicated in the pathogenesis of major depression may result from functi...