geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Assay for identifying agents that inhibit chromosome non-disjunction


, : Assay for identifying agents that inhibit chromosome non-disjunction. Official Gazette of the United States Patent & Trademark Office Patents 1228(3), Nov 16

Disclosed is a method of identifying genes whose gene products cause chromosome missegregation. The method involves transfecting a mammalian gene being assessed into a cell and then assessing whether the progeny cells have increased aneuploidy or increased chromosome breaks or translocations compared with cells that have not been transfected with the gene. Genes identified in this manner are likely to be involved in causing diseases such as cancer and Alzheimer's Disease, which result from improper chromosome segregation. Also disclosed is a method of identifying agents which can be used in the treatment of diseases caused by improper chromosome segregation. The method involves treating cells that have been transfected with a gene whose gene product causes improper chromosome segregation with an agent being assessed. Cells showing less aneuploidy or less chromosomal breakage or translocation compared with untreated cells indicate that the agent is useful in the treatment of diseases caused by improper chromosome segregation.

US$29.90


Other references

Brummer, S.B.; Turner, M.J., 1977: Electrochemical considerations for safe electrical stimulation of the nervous system with platinum electrodes. IEEE Transactions on Bio-Medical Engineering 24(1): 59-63

Shukla U.C.; Mittal S.B., 1980: Characterization of the zinc retained in some soils of india using ph gradient elution. Zn retained in soils was characterized by studying its solubility characteristics in continuous elution with a pH gradient solution and equilibrium extraction in 1N NH4OAc [ammonium acetate] (pH 7.0), 1N HCl and 6N HCl, and relating these to the s...

Irish E.J.W., 1970: Geology; drumheller west of fourth meridian, Alberta. Geologic map 1:253,440, marginal descriptive notes.

Pardeshi V.N.; Pokle D.S., 1974: Notes on the distribution of some flowering plants from aurangabad maharashtra india. Bulletin of the Botanical Survey of India 16(1-4): 161-163

Tümmler, B.; von der Hardt, H.; Müller, W.; Rieger, C., 1982: Cystic fibrosis: long-term treatment at a specialized centre, and its prognostic value. Data are presented on morbidity, mortality, and age at diagnosis of 90 patients with cystic fibrosis who were seen at the Medical School of Hannover from 1975 to 1981. The status of patients was characterized by the clinical score and the score of...

Labovitz A.J.; Williams G.A.; Nelson J.; Habermehl K.; Windhorst D.M.; Kennedy H.L., 1985: Prosthetic heart valve examination by doppler echocardiography. Clinical Research 33(2 PART 1): 202A

Pasco, S.; Wallack, C.; Sartin, R.M.; Dayton, R., 2012: The impact of experiential exercises on communication and relational skills in a suicide prevention gatekeeper-training program for college resident advisors. In an effort to identify students at risk for suicide, many colleges are implementing suicide prevention training for campus gatekeepers. This study evaluated the efficacy of a 3-hour, experiential-based gatekeeper training that included an emphas...

Pena, R.S. de la, 1971: The edible aroids in the Asian-Pacific area. The importance and nutritive value of tania, cocoyam and Amorphophallus campanulatus in the area are briefly reviewed.

Wulle, C., 2010: Complex regional pain syndrome versus chronic regional pain syndrome (Hand-Finger Syndrome). Dystrophy is a main factor of CRPS. A large number of patients do not develop dystrophy but, instead, they suffer from pain with limitation in movement, possible paraesthesia and/or swelling. This is then a chronic regional pain syndrome or (shoul...

Bassu, U.P.; Bose, A.N., 1941: Toxicity of a dialkyl-amino alkylamino acridine akin to atabrin. The dihy-drochloride of 2-chloro-7-methoxy-5(5-diethylaminobutyl) aminoacridine was prepared by the condensation of 5-di-ethylaminobutylamine with 2:5dichlor-7-methoxyacridine. The toxicity of this compound was compared with that of atabrin. It wa...