geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Combinatorial transcriptional regulation: the interaction of transcription factors and cell signaling molecules with homeodomain proteins in Drosophila development


, : Combinatorial transcriptional regulation: the interaction of transcription factors and cell signaling molecules with homeodomain proteins in Drosophila development. Critical Reviews in Eukaryotic Gene Expression 11(1-3): 145-171

Patterning and cell fate specification during development require complex interplay among multiple families of transcription factors to establish, maintain, and coordinate transcriptional cascades. During these processes, homeodomain proteins and cell signaling proteins cooperate to generate tissue-and stage-specific responses. This review of physical and genetic interactions in Drosophila melanogaster development highlights the cross-talk among these protein families. Protein-protein association can modulate regulation by both signal transduction-regulated transcription factors and homeodomain proteins, as observed in Drosophila and other organisms. Enhancers or genes regulated by multiple transcription factors provide opportunities for protein-protein binding to modulate transcription factor function. Combinatorial regulation of several enhancers by homeodomain proteins and cell signaling-regulated transcription factors is discussed; detailed maps of the genetic interactions that pattern the embryonic midgut and the larval wing imaginal disc are used to illustrate the multiplicity of potential protein-protein interactions. These interactions potentially provide direct mechanisms for communication between transcription factors as well as for generating the requisite functional specificity.

US$29.90

PMID: 11693959


Other references

Krempien, Burkhard, 1967: Aging processes of the vessels bridging between the dura mater cerebri and the calvaria Relationship with Pachymeningosis interna. In histological studies of 30 calvariae (with attached dura mater) from various ages between 4 1/2 weeks to 78 years, an orderly process of aging of the vessels bridging between meninges and bone was disclosed. The biological alterations (biorheos...

Yang, K.P.; Sowell, R.S., 1979: Selecting components of flue-cured tobacco harvesting and curing systems. A mathematical optimization model and a computer simulation model are used for the selection of components of a flue-cured tobacco harvesting and curing system. With the model the optimum harvest schedule, numbers and sizes of harvesters and curin...

Pasricha, N.S.; Randhawa, N.S., 1975: Effect of sulfur fertilization on the nitrogen metabolism in berseem. The effect of S supplied from 3 sources on the N metabolism in berseem (Trifolium alexandrinum Juslen) was studied in the greenhouse. Hot-water-soluble N in oven-dried plant tissue was fractionated into amide, nitrate and amino acid N; protein N w...

Finckh, A., 2016: Reactive arthritis: inflammation or true infection?. Reactive arthritis has been classically defined as an aseptic arthritis induced by a bacterial infection in another organ. If the classical form of reactive arthritis is in fact a spondyloarthritis triggered by a urogenital or intestinal bacterial...

Hofman, J., 1968: The origin of Taxus baccata in the Chudenice region. On the basis of annual-ring analyses, the author suggests that the existing trees are of secondary origin, and not natural relicts, as was previously assumed.

Motoi, Y.; Takanashi, M.; Itaya, M.; Ikeda, K.; Mizuno, Y.; Mori, H., 2004: Glial localization of four-repeat tau in atypical progressive supranuclear palsy. In the present case, a patient in whom limb apraxia and asymmetrical parkinsonism developed suggesting corticobasal degeneration, is reported. Neuropathologic examination revealed numerous tufted astrocytes in the precentral cortex in addition to...

Brunn, A.F., 1941: Observations on North Atlantic fishes. 1. Acanthocottus lilljeborgi. 2. The Ammodytes luncea group. Videnskabelige Meddelelser fra Dansk Naturhistorisk Forening I Kjobenhavn, 104: 323-340

Griffith, G.S.; Cook, R.; Mizen, K.; Anthony., 1999: Effects of temperature on stem nematode (Ditylenchus dipsaci) infestation of white clover (Trifolium repens) swards. Development of D. dipsaci infestations of T. repens in artificially established swards and transplanted turfs was monitored at field sites in Wales with different mean daily temperatures. In artificial swards the level of nematode infestation was...

Renick, O.; Hale, J.; Metzler, L., 2002: The searchers, II: How consumers can find cost-effective, quality health care. The original "Searchers" article appeared in the March 2000 issue of Employee Benefits Journal. It described the use of a patient satisfaction survey at Southwest Texas State University (SWT) to assist employees at the annual open enroll...

Shchurevskii, Ve, 1980: Diagnostics of tuberculosis of cattle and the system of measures in prophylaxis and elimination of this disease on farms. Trudy Vsesoiuznogo instituta eksperimental'noi veterinarii1(51): 30-35