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Compositions and methods for treatment of staphylococcal infection while suppressing formation of antibiotic-resistant strains


, : Compositions and methods for treatment of staphylococcal infection while suppressing formation of antibiotic-resistant strains. Official Gazette of the United States Patent & Trademark Office Patents 1270(4), May 27

Co-administration of a lysostaphin or other anti-staphylococcal agent which cleaves cross-links of peptidoglycans of staphylococci cell walls such as lysostaphin and an antibiotic effective against staphylococci due to antibiotic activity mediated by cell-wall activity is effective against staphylococcal infection, even staphylococci that may be resistant to one or other of lysostaphin or the cell-wall active antibiotic. Co-administration simultaneously suppresses the generation of antibiotic-resistant mutant strains. Effective cell-wall active antibiotics include beta-lactams and glycopeptides.

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