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Compositions for increasing the MRI contrast in visualizing the digestive tract of patients

, : Compositions for increasing the MRI contrast in visualizing the digestive tract of patients. Official Gazette of the United States Patent & Trademark Office Patents 1247(1), June 5

The invention provides, as contrast signal generators in MR imaging of the digestive tract, paramagnetic metal chelates of novel acrylic compounds of formula C(R1 R2)dbdCR3 --CO--Z--Z (1) and/or C(R1 R2)dbdCR3 --CO--Z--Z--Z--CO--CR3dbdC(R1 R2) (2) in monomer, oligomer, homopolymer and copolymer forms, in which the R1, R2 and R3 represent H or saturated or unsaturated C1-10 aliphatic radicals optionally substituted by one or more OH groups; Z is a covalent bond or a linker spacer and A is a moiety capable of fixing a paramagnetic metal by chelation. Compounds of type (1) useful in the present invention are, for instance the polyalkylene-aminopolycarboxylic acids such as NTA, EDTA, DTPA, DOTA and like structures, possibly involving additional substituents; an example is the compound BOPTA which is a DTPA derivative carrying a benzyloxypropyl group.


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