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Corticostriatal plasticity induced by IN - 1 antibody in the dorsocentral striatum of rats


, : Corticostriatal plasticity induced by IN - 1 antibody in the dorsocentral striatum of rats. Society for Neuroscience Abstract Viewer & Itinerary Planner : Abstract No 601 3

Dorsocentral striatum (DCS) is an associative region involved in directed attention. Plasticity in DCS is correlated with recovery of function from neglect. Major cortical input to DCS originates from medial agranular cortex (AGm), more densely from ipsilateral AGm. We investigated the ability of IN-1, an antibody to the neurite inhibitory factor NOGO-A, to induce sprouting in this system. The left AGm was lesioned, removing the projection from left AGm to DCS. A 6mul cell suspension containing 1x105 IN-1 secreting hybridoma cells was injected into the ipsilesional ventral hippocampus. Control animals received cells secreting anti-horseradish peroxidase (HRP). After survival times of 4-6 weeks a second surgery was performed in which the anterograde axonal tracer biotinylated dextran amine was injected into contralesional (right) AGm. Image processing including histogram normalization, contrast optimization, and a modified Laplacian filter was used to extract BDA-labeled axons from background features. We assessed the degree of sprouting by quantifying axon density within the central region of DCS on both sides and computing the left/right axon density ratio. Fascicles of the internal capsule were excluded and shrinkage effects were not a factor. Unoperated controls and HRP hybridoma controls had axon density ratios ranging from 0.33-0.47. The IN-1 experimental group had ratios ranging from 0.85-1.31, indicating that axons originating from contralesional (right) AGm had undergone robust sprouting in the opposite DCS. These data have implications for promoting functional recovery from neglect through the use of antibodies to myelin-associated neurite outgrowth inhibitors.

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