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Corticotropin release inhibiting factor and methods of using same for treating behavioral symptoms in an anxiety disorder

, : Corticotropin release inhibiting factor and methods of using same for treating behavioral symptoms in an anxiety disorder. Official Gazette of the United States Patent & Trademark Office Patents 1232(3), Mar 21

The invention includes a substantially pure preparation of a peptide having corticotropin release inhibiting factor (CRIF) activity comprising at least three contiguous amino acids contained within the amino acid sequence positioned between the fourth and fifth thyrotropin releasing hormone (TRH) sequence on a prepro-TRH protein. The CRIF peptide further comprises the fourth uncleaved TRH portion of prepro-TRH positioned at the amino terminus of CRIF. Compositions, methods of diagnosis and methods of treating CRIF related diseases are also included in the invention.


Other references

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