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Cranberry extract and its purified phytochemicals inhibit the proliferation of human tumor cell lines synergistic effects


, : Cranberry extract and its purified phytochemicals inhibit the proliferation of human tumor cell lines synergistic effects. FASEB Journal 18(4-5): Abst 270 2

Cranberries (Vaccinum macrocarpon Ait.) are an excellent dietary source of phytochemicals. Cranberry extract (CE) was separated into its constituent fractions including sugars, organic acids, total polyphenols, proanthocyanidins and anthocyanins. The antiproliferative effects of CE (200 μg/mL) vs. all fractions (at concentrations normalized to their % composition in CE) were evaluated against a panel of human oral (KB, CAL27), colon (HT-29, HCT116, SW480, SW620) and prostate (RWPE-1, RWPE-2, 22Rv1) cancer cell lines. The total polyphenols (21.22 μg/mL) was the most active fraction against all cell lines with 96.1 and 95% inhibition of KB and CAL27 oral cancer cells, respectively. For the colon cancer cells, the antiproliferative activity of this fraction was greatest against HCT116 (92.1%) than HT-29 (61.1%), SW480 (60%) and SW620 (63%). CE and all fractions showed &(ge)50% antiproliferative activity against prostate cancer cells, with total polyphenols being the most active fraction (RWPE-1, 95%; RWPE-2, 95%; 22Rv1, 99.6%). The sugar fraction (78.8 μg/mL) did not inhibit the proliferation of the cancer cell lines. The enhanced antiproliferative activity of cranberry polyphenols compared to the total extract and its individual phytochemicals suggests synergistic or additive antiproliferative interactions of the anthocyanins, proanthocyanidins and flavonol glycosides within the cranberry extract. Supported by NIH AT00151, NIH CA42710.

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