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Deactivating active memories


, : Deactivating active memories. Society for Neuroscience Abstract Viewer & Itinerary Planner : Abstract No 186 14

Are the mechanisms governing memory consolidation and reconsolidation the same or are they fundamentally distinct from each other? Currently there is much effort in attempting to discriminate between consolidation and reconsolidation. Does protein synthesis play a similar role in both processes? We provide evidence that reconsolidation of a LTM in the snail Lymnaea stagnalis can be disrupted by cold shock, protein synthesis blockers, and by specifically ablating the soma of a cell we know is a site of LTM consolidation (RPeD1).)Snails received four 45 min training sessions over the course of 2 days (Days 1-2). One week after the first training session (Day 8), snails were split into 4 groups: i) memory retrieval immediately followed by either a 1 hr cold shock or Act D injection; ii) memory retrieval followed by either no cold shock or a saline injection; iii) no memory retrieval with either a 1 hr cold shock or Act D injection; and iv) no memory retrieval with either no cold shock or a saline injection. Only the snails that received a memory retrieval session followed by either a 1 hr cold shock or Act D injection showed disrupted memory when tested 4 hours later (Group i); all other groups showed robust memory (Groups ii-iv). The above protocol was also utilized to demonstrate that the soma of RPeD1 is specifically needed for reconsolidation except that the memory retrieval session was given on Day 4 immediately followed by the ablation of either RPeD1 or LPeD1 (sham surgery). Memory was subsequently tested 4 days later (Day 8) to allow for full surgical recovery. Only the snails that received a memory retrieval session followed by ablation of RPeD1 showed deficits in memory while all other groups demonstrated memory.

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