+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Decline in early life mortality in a high HIV prevalence rural area of South Africa: evidence of HIV prevention or treatment impact?

, : Decline in early life mortality in a high HIV prevalence rural area of South Africa: evidence of HIV prevention or treatment impact?. Aids 24(4): 593-602

Objective: We present early life mortality rates in a largely rural population with high antenatal HIV prevalence, and investigate temporal and spatial associations with a prevention of mother-to-child transmission (PMTCT) programme, an HIV treatment programme, and maternal HIV. Design: A retrospective cohort analysis. Methods: All births from January 2000 to January 2007 to women in the Africa Centre demographic surveillance were included. Under-two child mortality rates (U2MR) computed as deaths per 1000 live-births per year; factors associated with mortality risk assessed with Weibull regression. Availability of PMTCT (single-dose nevirapine; sdNVP) and antiretroviral therapy (ART) in a programme included in multivariable analysis. Results: Eight hundred and forty-eight (6.2%) of 13 583 children under 2 years died. Deaths in under twos declined by 49% between 2001 and 2006, from 86.3 to 44.1 deaths per thousand live-births. Mortality was independently associated with birth season (adjusted hazard ratio 1.16, 95% confidence interval 1.02-1.33), maternal education (1.21, 1.02-1.43), maternal HIV (4.34, 3.11-6.04) and ART availability (0.46, 0.33-0.65). Children born at home (unlikely to have received sdNVP) had a 35% higher risk of dying than children born in a facility where sdNVP was available (1.35, 1.04-1.74). For 2005 births the availability of PMTCT and ART in public health programmes would have explained 8 and 31% of the decline in U2MR since 2000. Conclusion: These findings confirm the importance of maternal survival, and highlight the importance of the PMTCT and especially maternal HIV treatment with direct benefits of improved survival of their young children.


PMID: 20071975

DOI: 10.1097/QAD.0b013e328335cff5

Other references

Ehlenz K.; Dugi K.; Weber K.; Schneider H.; Peter J.H.; Von Wichert P.; Kaffarnik H., 1989: Renin secretion during sleep in patients with obstructive sleep apnea syndrome osas before and during ncpap therapy. European Journal of Clinical Investigation 19(2 PART 2): A44

Huang, D.C.; Zhang, D.Y.; Liu, Z.Z.; Wang, Z.Y.; Zhao, W.J., 1990: Studies on recurrent selection for resistance to wheat scab. Three wheat populations derived from different selection cycles were compared under artificial field infection conditions to examine the effect of recurrent selection on improvement of resistance to scab (Gibberella zeae). Disease incidence, disea...

Black, P., 2001: Guided self management plans for asthma. Focus on regular follow up and repeated education may be more productive. Bmj 322(7294): 1122-3; Author Reply 1123

Van Lancker J.L., 1968: The role of an academic department of pathology editorial human. Laboratory Investigation 19(3): 253-255

Sharma, R.A., 1997: Influence of conjunctive use of organics and fertilizer nutrients on nutrient uptake and productivity of soybean-safflower cropping sequence in typic chromusterts. A field experiment was conducted for two consecutive years (1992-93 to 1993-94) to study the effect of different levels of N, P, FYM, crop residues and conjunctive application of organics and fertilizer sources of nutrients on nutrient uptake, wat...

Natke, U.; Sandrieser, P.; van Ark, M.; Pietrowsky, R.; Kalveram, K.Theodor., 2004: Linguistic stress, within-word position, and grammatical class in relation to early childhood stuttering. The purpose of the present study was to investigate whether the link that has been established between stuttering and linguistic stress in adolescents and adults (the so-called stress effect) can also be observed in childhood stuttering. To accoun...

El Haj, M.; Nandrino, J-Louis., 2017: Phenomenological characteristics of autobiographical memory in Korsakoff's syndrome. A body of research suggests compromise of autobiographical memory in Korsakoff's syndrome (KS). The present paper extends this literature by investigating the subjective experience of autobiographical recall in the syndrome. Patients with KS...

Zaizov R., 1977: Effect of intra uterine growth on erythropoiesis in the rabbit. Pediatric Researchpart 1: 57

Ciuffolo, F.; Manzoli, L.; D'Attilio, M.; Tecco, S.; Muratore, F.; Festa, F.; Romano, F., 2005: Prevalence and distribution by gender of occlusal characteristics in a sample of Italian secondary school students: a cross-sectional study. The aim of this study was to describe the prevalence and distribution, by gender, of occlusal traits in a sample of Italian students aged 11-14 years (mean 13 +/- 1 years). Using standardized and validated recording criteria, a single operator mea...

Hong, W.; Guan, K-Liang., 2012: The YAP and TAZ transcription co-activators: key downstream effectors of the mammalian Hippo pathway. The Hippo signaling pathway was initially defined by genetic studies in <italic>Drosophila</italic> to regulate tissue growth and organ size <cross-refs refid="bib5 bib1">[1,2]</cross-refs>. This pathway is highly...