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Design and application of multimodular peptide synthetases

, : Design and application of multimodular peptide synthetases. Current Opinion in Biotechnology 10(4): 341-348

Nonribosomal peptide synthetases produce bioactive peptides of great structural diversity. Their modular organization makes them amenable to the construction of hybrid enzymes that synthesize novel products. New strategies for combinatorial approaches are being developed from the recent advances in nonribosomal peptide synthesis on the genetic, biochemical and structural level.


PMID: 10449311

DOI: 10.1016/S0958-1669(99)80062-7

Other references

Atanassova, I.; Damyanova, I., 2003: Bioavailability of trace elements in soils from North Bulgaria. II. Cu and Pb. This study was conducted to determine the bioavailability of Cu and Pb to sugarbeet plants grown on a wide range of soils (grey and dark grey forest soils, leached chernozems, typical chernozems and calcareous chernozems) in northern Bulgaria. The...

Zhang XinBao; Q.Y.ngQing; H.X.uBin; Wen AnBang; F.J.eXiong, 2006: Dating of reservoir and pond deposits by the 137Cs technique to assess sediment production in small catchments of the Hilly Sichuan basin and the Three Gorges Region, China. There is a huge number of small reservoirs and ponds with quite high deposition rates in the Hilly Sichuan basin and Three Gorges Region, China. Ponds in four small catchments in Yanting and Nanchong of Sichuan Province and Kaixian of Chongqing we...

Friedman, D.L.; Johnson, R.A.; Zeilig, C.E., 1976: The role of cyclic nucleotides in the cell cycle. Advances in Cyclic Nucleotide Research 7: 69-114

Obata, T.; Yamanaka, Y., 2000: Block of cardiac ATP-sensitive K(+) channels reduces hydroxyl radicals in the rat myocardium. The present study examined whether opening of an ATP-sensitive K(+) (K(ATP)) channel can induce hydroxyl free radical ((*)OH) generation in the rat myocardium. Sodium salicylate in Ringer's solution (0.5 nmol/microl/min) was infused directly...

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Mirza, J.H.; Khan, S.M., 1979: Studies on the coprophilous ascomycetes of pakistan 3. semidelitschia tetraspora new species. S. tetraspora sp. nov. is described. This fungus resembles S. agasmatica in the apical asci apparatus, spore color, shape, septation and germ slip presence. It has smaller perithecia, asci and ascospore dimensions; it always has 4-spored asci.

Kristenson, M.; Olsson, A.G.; Kucinskiene, Z., 2005: Good self-rated health is related to psychosocial resources and a strong cortisol response to acute stress: the LiVicordia study of middle-aged men. Self-rated health (SRH) is a strong predictor for disease and death. The relations among SRH, psychosocial factors, and cortisol dynamics were tested using pooled data from the LiVicordia study of 50-year-old men in Lithuania (n = 94) and Sweden (...

Hwang, H.Suk.; Yang, E.Jin.; Lee, S.Min.; Lee, S.Cheol.; Choi, S-Mi., 2011: Antiallodynic Effects of Electroacupuncture Combined with MK-801 Treatment through the Regulation of p35/p25 in Experimental Diabetic Neuropathy. The anti-allodynic effect of NMDA receptor antagonist and acupuncture treatments were explored through spinal p35 regulation of diabetic neuropathic rat. We evaluated the change over time of p35/p25 protein levels in the spinal cord compared with...

Sahu, S.B.; Pandit, S.K., 1999: Dicephalus thoraco - Sternopagus siamese monster in a buffalo A case report. Indian Veterinary Journal 76(8): 745-746, Aug

Stout, S.J.; Steller, W.A.; Manuel, A.J.; Poeppel, M.O.; daCunha, A.R., 1984: Confirmatory method for sulfamethazine residues in cattle and swine tissues, using gas chromatography--chemical ionization mass spectrometry. A gas chromatographic (GC) method has been reported for the determination of sulfamethazine residues in cattle and swine tissues. The extracts from this procedure were found to be directly amenable to examination by gas chromatography-mass spectro...