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Designing chiral libraries for drug discovery

, : Designing chiral libraries for drug discovery. Drug Discovery Today 5(8): 364-372

Identification of new biological targets combined with combinatorial medicinal chemistry has enormous potential to facilitate the discovery of new therapeutics. However, these new targets might require the use of different or more complex screening libraries. This complexity might be achieved through the use of new templates or the identification of new chemistries. One approach is the use of chiral libraries that have been designed using three-dimensional pharmacophore and shape descriptors to provide maximal structure–activity information after screening. The advantages of using a designed chiral library in primary screening and the information one should obtain are discussed.


PMID: 10893549

DOI: 10.1016/s1359-6446(00)01515-4

Other references

Ware S., 1991: Influence of interspecific competition light and moisture levels on growth of rock outcrop talinum portulacaceae. Both Talinum calcaricum Ware of the shallow soil of limestone outcrops and T. mengesii Wolf of similar habitat on sandstone outcrops were greatly reduced in growth in competition with the grass Poa pratensis L., and both were less inhibited as gra...

Mikolajewski, A.J.; Taylor, J.; Iacono, W.G., 2017: Oppositional defiant disorder dimensions: genetic influences and risk for later psychopathology. This study was undertaken to determine how well two oppositional defiant disorder (ODD) dimensions (irritable and headstrong/hurtful) assessed in childhood predict late adolescent psychopathology and the degree to which these outcomes can be attr...

Guyer, R.L., 1991: This Week in SCIENCE. Science 251(4999): 1287-1287

Ulrich, A.; Hellstern, P.; Lüthi, S.; Study, S.; Spirig, R., 2010: Failures can improve nursing practice. Krankenpflege. Soins Infirmiers 102(10): 16-19

Block, B.S.; Goodner, D.M., 1979: False-positive amniotic fluid cytology in a parturient with active genital herpes infection at term. A patient who developed genital herpes infection diagnosed at 37 weeks' gestation is presented. Amniocentesis performed at 38 weeks' gestation revealed herpetic changes in fetal cells. Subsequent amniotic fluid viral culture was negative...

Anonymous, 2016: Editorial. Pediatrics International 58(10): 961-962

Tintinalli, J.E.; White, B.C., 1981: Transthoracic pacing during CPR. Twenty-seven patients had transthoracic pacemakers inserted by the subxiphoid approach during advanced cardiopulmonary resuscitation (CPR) in the emergency department of Detroit General Hospital between May 1977 and March 1979. Twenty-one charts w...

Geudens, A.; Sandra, D.; Van den Broeck, W., 2004: Segmenting two-phoneme syllables: developmental differences in relation with early reading skills. This study explored developmental differences in children's segmentation skills of VC and CV syllables (e.g., /af/ and /fa/) in relation to their early reading abilities. To this end, we followed a subgroup of Dutch speaking prereaders who pa...

Rodin, VE.; Shuntov, VP.; Gavrilov, GM.; Fadeev, NS.; Novikov, YuA.; Pavlychev, VP.; Chuchukalo, VI.; Kucheryavenko, EB., 1985: Seldevye severnoi chasti tikhogo okeana.. Unknown

Arcuri, F.; Robert, L.; Piersantelli, N., 1966: The immunoglobulin distribution of Hoyt-Morrison heteroagglutinins during viral hepatitis. The heteroagglutinins isolated by the Hoyt-Morrison test from the sera of 25 patients belong to IgG [immunoglobulin G], IgG and IgM, or to IgM only. The heteroagglutinins derived from altered protein synthesis resulting from the effects of the hep...