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Developing models of autoimmune disease systemic lupus erythematosus in rabbit


, : Developing models of autoimmune disease systemic lupus erythematosus in rabbit. FASEB Journal 18(4-5): Abst 562 14

The unique nature of our allotype-defined rabbit colony facilitates studies to develop strains genetically susceptible to autoimmune disease. Our focus here is a rabbit model of Systemic Lupus Erythematosus (SLE). SLE is a multisystemic autoimmune disease characterized by autoantibodies to nuclear antigens including dsDNA, Sm, Rnp, SS-A and SS-B. Clinical symptoms may include rash, inflammation (nephritis, arthritis) and neuropsychiatric dysfunction (cognitive decline, psychosis, seizures). Extending earlier published reports, we immunized 6 rabbits with an Sm B/B&39;-derived peptide on a MAP-8 backbone (BB), 4 with an NMDA-derived peptide on BB, and 2 with BB alone. Antisera collected over 9 months and tested by ELISA for antibodies to dsDNA, Sm, Rnp, SS-A and SS-B showed that 5 of the peptide-immunized rabbits developed Lupus-like serology. All rabbits were monitored continually by video cameras with night-vision. Two had seizure-like events, and a third nystagmus. Characterization of the specificity patterns of anti-dsDNA and anti-NMDA-peptide antibodies is underway. Immunohistochemical and microscopic examination of tissues from diverse organs, collected after sacrifice, for immune complex deposition and other pathology is also in progress. The genetically related progeny of these immunized rabbits are now included in our follow-up study.

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Other references

Ghizdavu, J.; Ghizdavu, L., 1976: Spectrum of resistance to insecticides in a romanian strain of musca domestica. From topical and tarsal contact applications, the resistance levels to 16 of the most important insecticides of a Romanian strain (I.A.C.) of Musca domestica were determined. The strain is very sensitive to nicotine, DDVP, parathion, fenitrothion,...

Schlittenlacher, J.; Ellermeier, W.; Hashimoto, T., 2015: Spectral loudness summation: shortcomings of current standards. There are two competing national standards for the calculation of loudness of steady sounds, DIN 45631 and ANSI S3.4. Their different concepts of critical bands lead to different predictions for broadband sounds. As that discrepancy is neither con...

Yao, J.; Yang, W.; Liu, Y.; Sun, Y-Xi.; Jiang, Q., 2012: Dexamethasone inhibits TGF-β2-induced migration of human lens epithelial cells: implications for posterior capsule opacification prevention. The elevation of transforming growth factor-β2 (TGF-β2) levels in eye tissue is considered as one of the major factors contributing to posterior capsule opacification (PCO) in patients undergoing cataract surgery, since TGF-β2 is known to stimu...

Carretero M.E.; Serranillos Fernandez M.G., 1981: New studies of allium cepa common onion. Archivos de Farmacologia y Toxicologia 7(1): 193-196

Crespon B.; Mendez J.; Housset P.; Debray C., 1975: Recent data on coloscopy in cancer of the colon. Annales de Gastroenterologie et d'Hepatologie (3): 229-233

Powell, A.W.B., 1965: New Zealand molluscan systematics with descriptions of new species: part 5. Records of the Auckland Institute and Museum, 6: 161-168

Quraishy Mohamed Saleh, 1944: The origin of curves in rivers. A series of laboratory tests leads to the conclusion that skew shoals are responsible for the origin of curves in rivers, which initially had been straight with an even bed.

Kluth, L.A.; Rink, M.; Ahyai, S.A.; Fisch, M.; Shariat, S.F.; Dahm, P., 2014: Randomized controlled trials terminated prematurely: beneficial therapy effects. Randomized controlled trials (RCTs) stopped prematurely for beneficial therapy effects are becoming increasingly more prevalent in the urological literature and often receive great attention in the public and medical media. Urologists who practice...

Hueppe J., 1987: Changes in the polygono chenopodietalia communities in the westphalian basin west germany during the past 40 years. Since little is known about changes in the root crop and maize crop communities, these relationships were examined in the Westphalian Basin. The results showed that an unexpectedly large group of plants, mostly nitrophilous, resistant ubiquists, h...

Kamada, K.; Ohta, K.; Kubo, T.; Shimizu, A.; Morita, Y.; Nakasuji, K.; Kishi, R.; Ohta, S.; Furukawa, S-ichi.; Takahashi, H.; Nakano, M., 2007: Strong two-photon absorption of singlet diradical hydrocarbons. Angewandte Chemie 46(19): 3544-3546