geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Development of anti-TNF therapy for rheumatoid arthritis


, : Development of anti-TNF therapy for rheumatoid arthritis. Nature Reviews. Immunology 2(5): 364-371

The aetiology of systemic, autoimmune, chronic inflammatory diseases--such as rheumatoid arthritis--is not known, and their pathogenesis is complex and multifactorial. However, progress in the characterization of intercellular mediators--proteins that are now known as cytokines--has led to the realization that one cytokine, tumour-necrosis factor (TNF; previously known as TNF-alpha), has an important role in the pathogenesis of rheumatoid arthritis. This discovery heralded a new era of targeted and highly effective therapeutics for rheumatoid arthritis and, subsequently, other chronic inflammatory diseases.

US$19.90

PMID: 12033742

DOI: 10.1038/nri802


Other references

Egorova, E.V., 1970: Local treatment of trichomonal colpitis and candidiasis of the vagina. Treatment of 102 patients with candidosis of the vagina and trichomonal colpitis (9 had a combination of these diseases) with pimafucin in the form of vaginal tablets for 20 days showed good results in 85. The drug was ineffective in 15 and there...

Bagg, W.K.; Newland, M.C.; Rule, H., 2004: Commissioning and operational experiences for the 160ML/d Woodman Point Sequencing Batch Reactor--control of settleability and denitrification using bioselectors. Achieving and maintaining good biomass settling characteristics is a critical process design objective for any activated sludge wastewater treatment plant (WWTP), whether intermittent or continuous technology. One way of ensuring good sludge settl...

van den Pol, A.N.; Acuna-Goycolea, C.; Clark, K.Reed.; Ghosh, P.K., 2004: Physiological properties of hypothalamic MCH neurons identified with selective expression of reporter gene after recombinant virus infection. Neurons that synthesize melanin-concentrating hormone (MCH) may modulate arousal and energy homeostasis. The scattered MCH neurons have been difficult to study, as they have no defining morphological characteristics. We have developed a viral appr...

Galton, V.A., 1988: Iodothyronine 5'-deiodinase activity in the amphibian Rana catesbeiana at different stages of the life cycle. In a previous study, 5' deiodinase (5'D) activity was detected in skin but not in other tissues of premetamorphic tadpoles. When these tadpoles were stimulated to metamorphic climax by treatment with thyroid hormone, activity was increas...

Yamasaki, M.; Kanemura, Y., 2015: Molecular Biology of Pediatric Hydrocephalus and Hydrocephalus-related Diseases. We are beginning to understand the molecular biology of hydrocephalus and its related diseases. X-linked hydrocephalus (XLH), holoprosencephaly (HPE), Dandy-Walker malformation (DWM), and neural tube defect (NTD) can all be discussed with respect...

Weisberg, A.; Winegrad, S., 1997: Effect of phosphorylation of C protein on cross bridges in cardiac muscle. Biophysical Journal 72(2 PART 2): A276

Brinkman, J-Martijn.; Hurschler, C.; Agneskirchner, J.; Lobenhoffer, P.; Castelein, Ré.M.; van Heerwaarden, R.J., 2014: Biomechanical testing of distal femur osteotomy plate fixation techniques: the role of simulated physiological loading. Implants for fracture and/or osteotomy fixation are often tested according to basic mechanical test models such as open gap tests or 4-point-bending tests. These may be suitable to test and compare different implants for safety and clinical approv...

Sulaiman, V.R.; Holt, G., 2004: Extension, poverty, and vulnerability in India. This chapter examines (i) rural poverty in India, (ii) the country's policies towards agricultural and rural development, (iii) the background and status of agricultural extension in the country, and (iv) the opportunities and constraints in...

Gustafson, D.; Horak, M.; Rempel, C.; Metz, S.; Gigax, D.; Hucl, P., 2005: An empirical model for pollen-mediated gene flow in wheat. The extent of pollen-mediated gene flow (PMGF) in wheat (Triticum spp. L.) as a function of distance from a pollinator source has been measured in recent field studies. Wheat is primarily self-pollinated; however, some cross-pollination can occur...

Rahimi, M.; Babu, D.J.; Singh, J.K.; Yang, Y-Biao.; Schneider, Jörg.J.; Müller-Plathe, F., 2015: Double-walled carbon nanotube array for CO2 and SO2 adsorption. Grand-canonical Monte Carlo simulations and adsorption experiments are combined to find the optimized carbon nanotube (CNT) arrays for gas adsorption at low pressures and 303 K. Bundles of 3D aligned double-walled carbon nanotube (DWCNT) with inne...