geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Effects of estrogen on urethral function after pudendal nerve crush


, : Effects of estrogen on urethral function after pudendal nerve crush. Society for Neuroscience Abstract Viewer & Itinerary Planner : Abstract No 189 10

Stress Urinary Incontinence (SUI) is correlated with pudendal nerve injury and resultant denervation of the external urethral sphincter (EUS) after vaginal delivery. Symptoms of SUI typically surface during menopause, suggesting hormonal participation in its etiology. Estrogen is also a potent neuroregenerative agent and might be useful to promote recovery from nerve injury. In the present study, we sought to pinpoint the time, relative to pudendal nerve injury, that estrogen (E2) administration would have its greatest effect. The pudendal nerve was crushed in 58 ovariectomized virgin rats and 22 rats were used as sham controls. E2 was administered subcutaneously 6 days prior to nerve crush (n=14), at the time of nerve crush (n=16), or 2 days after nerve crush (n=14). Sham implants were given at the time of nerve crush (n=14). Seven days after nerve crush, the rats were anesthetized for leak point pressure testing. Gentle pressure was applied to each rat's abdomen and was slowly increased until leakage of saline through the urethra, followed by rapid removal of the pressure. Mean values of peak leak point pressure (LPP) and external abdominal pressure (Pabd), were calculated for each group. LPP and Pabd were significantly decreased 7 days after nerve crush compared to sham controls. Although no significant differences in LPP or Pabd were shown between the nerve crush group with no E2 and each of the 3 nerve crush groups with E2, a clear trend was observed. E2 given at the time of nerve crush resulted in increased LPP and Pabd compared to the nerve crush rats with no E2. A similar result was obtained when E2 was given after nerve crush. E2 pretreatment did not increase either LPP or Pabd, implying a sensitization of the EUS and/or pudendal nerve to E2. We conclude that estrogen may promote recovery from pudendal nerve injury when given concurrent with nerve injury.

US$29.90


Other references

Rüedi, T.; Allgöwer, M., 1978: Late results after operative treatment of fractures of the distal tibia (pilon tibial fractures). Unfallheilkunde 81(4): 319-323

Tsuji, J.S.; Maynard, A.D.; Howard, P.C.; James, J.T.; Lam, C-Wing.; Warheit, D.B.; Santamaria, A.B., 2005: Research strategies for safety evaluation of nanomaterials, part IV: risk assessment of nanoparticles. Nanoparticles are small-scale substances (< 100 nm) with unique properties and, thus, complex exposure and health risk implications. This symposium review summarizes recent findings in exposure and toxicity of nanoparticles and their applicatio...

Rajiv Kumar; Katoch, R.C.; Mandeep Sharma; Arvind Mahajan; Prasanjit Dhar, 2004: Pathoaetiology of pneumonic Gaddi goats in Himachal Pradesh. Lung tissues (190) of Gaddi goats were microbiological and histopathologically processed. Histopathology on lung tissues showed varying degree of emphysema, congestion and focal areas of haemorrhages along with oedema and polymorphonuclear cell in...

Miller, L.S.; Holt, S.C., 1977: Effect of carbon dioxide on pigment and membrane content in Synechococcus lividus. The effect of carbon dioxide on pigment and membrane content in Synechococcus lividus was studied by depriving cells of CO2 and examining cell populations biochemically and by electron microscopy. After 120 h of CO2 deprivation, S. lividus lost al...

Benson, Norman G., 1955: Observations on anchor ice in a Michigan trout stream. Anchor ice occurred in the Pigeon River, Otsego County, Michigan during early and late winter when the air temperature reached below 15[degree]C. It occurred principally in fast turbulent water. 10 samples of anchor ice on the bottom contained an...

Glerum, D.M.; Tzagoloff, A., 1994: Isolation of a human cDNA for heme A:farnesyltransferase by functional complementation of a yeast cox10 mutant. We have cloned the human homolog of the Saccharomyces cerevisiae COX10 gene by functional complementation of a yeast cox10 null mutant. The 2.8-kb cDNA encoding the human heme A:farnesyltransferase codes for a 443-aa protein with high homology to...

Graner, E.A.; Godoy, C.; Jr.; Godoy, O.P., 1961: The manuring and irrigation of coffee. Manuring combined with irrigation in the first year after planting out.. The planting holes for Mundo Novo coffee were filled with soil, soil + FYM, soil + NPK, or soil + FYM + NPK. In each treatment half the plants were irrigated during the dry season. The effects of irrigation on plant growth were not statistically s...

Terada, N.; Hamano, N.; Terada, Y.; Shirotori, K.; Ishikawa, K.; Togawa, K.; Konno, A., 1998: Changes in nasal responsiveness to histamine and to specific antigen after laser surgery. An initial treatment with several kinds of anti-allergic medicines is useful for reducing nasal allergy symptoms in patients suffering from Japanese cedar pollinosis during the pollen season. Since laser surgery before the pollen season seems to h...

Campbell, M.G.; Veesler, D.; Cheng, A.; Potter, C.S.; Carragher, B., 2016: 2.8 Å resolution reconstruction of the Thermoplasma acidophilum 20S proteasome using cryo-electron microscopy. Recent developments in detector hardware and image-processing software have revolutionized single particle cryo-electron microscopy (cryoEM) and led to a wave of near-atomic resolution (typically ∼3.3 Å) reconstructions. Reaching resolutions hi...

Jacobson R.D.; Skene J.H.P., 1985: Developmental regulation of a growth cone membrane protein growth associated protein 43 in rat central nervous system. Society for Neuroscience Abstracts 11(2): 760