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Fungal cell wall inhibitors: emphasis on clinical aspects

, : Fungal cell wall inhibitors: emphasis on clinical aspects. Current Pharmaceutical Design 6(2): 225-239

Invasive fungal infections, mainly caused by Candida and Aspergillus species, are an emerging cause of morbidity and mortality among all categories of immunocompromised patients. Currently available antifungal agents, both polyenes, flucytosine and (tri)azoles are hampered by serious infusion- or drug-related toxicity, by hazardous drug-drug interactions, or by pharmacokinetic problems and by the development of resistance, in vitro as well as in vivo. In recent years, several companies have become interested in antifungal drug development and have launched new compounds into preclinical and clinical trials. Some of these agents target the fungal cell wall in stead of the cell membrane. They exert their fungicidal action through inhibition of the synthesis of critical compounds of that fungal cell wall, not present in mammalian cells. Exciting and promising agents include inhibitors of beta-(1,3)-D-glucan synthase and inhibitors of chitin synthase. These drugs appear well tolerated in Phase I-II studies and will soon enter Phase III studies. This review wants to provide the clinical framework for assessing the utility of these agents compared to existing antifungals, thereby focusing on invasive fungal disease and emphasising the changing fungal epidemiology and susceptibility in immunocompromised hosts.


PMID: 10637377

DOI: 10.2174/1381612003401299

Other references

Karabinos Paul, 2003: Acadian transpression, extrusion, and gneiss dome formation in the New England Appalachians. Two N-S trending sets of gneiss domes in New England dominate the western Acadian belt. One belt is west of the Connecticut Valley trough (CVT) and is cored by fragments of Laurentian basement and rocks of the Early Ordovician Shelburne Falls arc...

Taheri, R.; Seyedhejazi, M.; Ghojazadeh, M.; Ghabili, K.; Shayeghi, S., 2012: Comparison of ketamine and fentanyl for postoperative pain relief in children following adenotonsillectomy. Adenotonsillectomy has a high incidence of postoperative pain. Therefore, the purpose of this study was to evaluate the effectiveness and safety of either ketamine or fentanyl for postoperative pain relief in children following adenotonsillectomy....

Snodgrass, B.Thomas., 2012: Vessels described by Thebesius and Pratt are distinct from those described by Vieussens and Wearn. American Journal of Cardiology 110(1): 160-160

Anderson, R.H., 1995: What is meant by tetralogy of Fallot [S,D,I. Annals of Thoracic Surgery 59(3): 562-564

Maggs A.F.; Pennington T.H., 1989: Temporal study of staphylococcal species on the skin of human subjects in isolation and clonal analysis of staphylococcus capitis by sds polyacrylamide gel electrophoresis. The staphylococcal skin floras of an isolated group of subjects were studied for 1 year. A wide variation in isolation patterns was found for different species. Staphylococcus intermedius, previously thought to be of veterinary origin, was found t...

Cseuz L.; Kertesz Z.; Pauk J., 1990: Combining ability of doubled haploid wheat lines. Three winter wheat cultivars and their double haploid analogues were crossed with 3 tester varieties in factorial fashion. F1 performances were analysed for plant height, grain yield/plant, spikes/plant, grains/main head and 1000 kernel weight. Co...

Voloch, M.J.nsen, N.; Ladisch, M.; Tsao, G.; Narayan, R.R.dwell, V., 1985: 2,3-butanediol. Comprehensive biotechnology: the principles applications and regulations of biotechnology in industry agriculture and medicine editor in chief Murray Moo Young: 947

Woersching, J.C.; Snyder, A.E., 2004: Earthquakes in El Salvador: a descriptive study of health concerns in a rural community and the clinical implications--part II. Results reported in Part I of the Earthquakes in El Salvador series (see Disaster Management & Response 2003;1:105-9) indicated clinically relevant findings. The findings indicated a need for greater public health action within all five catego...

Thiel, B.A., 1986: Silviculture for cool-climate farms. Garden (Bronx, NY) 10: 3

Braun, W., 1958: Cancer of the skin and inner organs caused by arsenic; contribution to late occupational sequelae caused by arsenic. Deutsche Medizinische Wochenschrift 83(20): 870-872