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Insulin-like growth factor-I regulates the liver microenvironment in obese mice and promotes liver metastasis


, : Insulin-like growth factor-I regulates the liver microenvironment in obese mice and promotes liver metastasis. Cancer Research 70(1): 57-67

Among the mechanisms implicated in the tumor-promoting effects of obesity, signaling by insulin-like growth factor-I (IGF-I) and insulin has received considerable attention. However, the emerging realization that obesity is associated with chronic inflammation has prompted other consideration of how the IGF-I axis may participate in cancer progression. In the present study, we used two mouse models of chronic (LID) and inducible (iLID) igf-1 gene deficiency in the liver to investigate the role of IGF-I in regulating the host microenvironment and colorectal carcinoma growth and metastasis in obese mice. Obese mice had a heightened inflammatory response in the liver, which was abolished in mice with chronic IGF-I deficiency (LID). In control animals changes to the hepatic microenvironment associated with obesity sustained the presence of tumor cells in the liver and increased the incidence of hepatic metastases after intrasplenic/portal inoculation of colon carcinoma cells. These changes did not occur in LID mice with chlonic IGF-1 deficiency. In contrast, these changes occured in iLID mice with acute IGF-1 deficiency, in the same manner as the control animals, revealing a fundamental difference in the nature of the requirement for IGF-1 on tumor growth and metastasis. In the setting of obesity, our findings imply that IGF-1 is critical to activate and sustain an inflammatory response in the liver that is needed for hepatic metastasis, not only through direct, paracrine effect on tumor cell growth, but also through indirect effects involving the tumor microenvironment.

US$19.90

PMID: 20048072

DOI: 10.1158/0008-5472.CAN-09-2472


Other references

Dudkina, AV.; Yashchenko, NF., 1972: Funicles in Deletrocephalus dimidiatus Strongylata. Problemy Parazit, 1: 286

Ellender, M.; Haines, J.W.; Harrison, J.D., 1995: The distribution and retention of plutonium, americium and uranium in CBA/H mice. Groups of male and female CBA/H mice were given intraperitoneal injections of 40 kBq kg-1 of 239Pu, 241Am and 233U citrate solutions and the retention and distribution of the three radionuclides compared at times up to 448 days. Similar results we...

Mahnel, H., 1977: Inactivation of viruses in drinking and surface water. Contribution to the decontamination of water by field methods. In studies with polio virus, ECBO, reo virus, bovine parvo virus, canine hepatitis, Aujeszky's, Newcastle disease and vaccinia viruses, heating of water up to 80 deg C was unreliable for disinfecting virus-contaminated water. Iodination appea...

Laugher, L.; Noctor, T.G.; Barrow, A.; Oxford, J.M.; Phillips, T., 1999: An improved method for the determination of fluticasone propionate in human plasma. Therapeutic monitoring of the potent, highly lipophilic glucocorticoid, fluticasone propionate (FP), was initially performed by a radioimmunoassay method. However an improved method with a lower limit of quantitation (LLOQ) of at least 25 pg per m...

Muskat, M.; Hutchisson, E., 1937: Symmetry of the Transmission Coefficients for the Passage of Particles through Potential Barriers. Proceedings of the National Academy of Sciences of the United States of America 23(4): 197-201

Kiil, A.D., 1975: Fire behaviour and the use of fire retardants in Canadian forests. The ignition and behaviour of fires are discussed in relation to environmental factors (meteorology, fuels and topography). The properties, methods of delivery, distribution patterns, and effectiveness of chemical fire retardants are reviewed. Tho...

Giovannucci, D.P.nte, S., 2005: Standards as a new form of social contract? Sustainability initiatives in the coffee industry. In the former age of national capitalism, the achievement of market fairness was embedded in a normative framework generated by government, labor unions, and perhaps religious authority. In the current age of global capitalism, new actors such as...

Rheams Karen F.; Neathery T.L.; Copeland C.W.; Rheams L.J., 1983: Oil bearing potential of Chattanooga Shale of North Alabama and south-central Tennessee. Abstracts with Programs - Geological Society of America 15(2): 68

Wijesinghe, W.A.J.P.; Ko, S-Chun.; Jeon, Y-Jin., 2011: Effect of phlorotannins isolated from Ecklonia cava on angiotensin I-converting enzyme (ACE) inhibitory activity. Inhibition of angiotensin I-converting enzyme (ACE) activity is the most common mechanism underlying the lowering of blood pressure. In the present study, five organic extracts of a marine brown seaweed Ecklonia cava were prepared by using ethanol...

Holtmeier, H.J., 1957: Significance of sodium chloride in the etiology of edema and hypertension. Deutsches Archiv für Klinische Medizin 204(2): 198-241