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Intraventricular administration of NT-3 retards kindling and inhibits kindling-induced mossy fiber sprouting in adult rats


, : Intraventricular administration of NT-3 retards kindling and inhibits kindling-induced mossy fiber sprouting in adult rats. Society for Neuroscience Abstracts 26(1-2): Abstract No -660 11

Kindling is an experimental epilepsy model in which repeated electrical stimulations of certain forebrain structures results in progressively more intense evoked electroencephalographic and behavioral seizures. Kindling also induces an increase in nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) expression, and infusions of NGF, BDNF and trkB receptorbodies have been shown to modulate kindling rates, kindling-induced mossy fiber sprouting, and kindling-induced changes in hilar area. On the other hand, both the mRNA and protein for neurotrophin-3 (NT-3) stay the same or even decrease following kindling. These results raise the possibility that NT-3 might play a different role in kindling epileptogenesis than either NGF or BDNF. In the present study, we demonstrated that continuous intraventricular infusion of NT-3 significantly retards kindling development and inhibits mossy fiber sprouting in the inner molecular layer of the dentate gyrus, suggesting an important role of NT-3 in seizure activity and synaptic reorganization.

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