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Isoprenoid-substituted flavonoids from wood of Artocarpus heterophyllus on B16 melanoma cells: cytotoxicity and structural criteria


, : Isoprenoid-substituted flavonoids from wood of Artocarpus heterophyllus on B16 melanoma cells: cytotoxicity and structural criteria. Fitoterapia 81(2): 120-123

As a result of cytotoxicity-guided fractionation, nine flavonoids, artocarpin (1), cudraflavone C (2), 6-prenylapigenin (3), kuwanon C (4), norartocarpin (5), albanin A (6), cudraflavone B (7), brosimone I (8) and artocarpanone (9) were identified from the methanol extract of the wood of Artocarpus heterophyllus, known commonly as Nangka in Indonesia. A structure-activity investigation of the effect of these isolated compounds (1-9) and structurally related compounds on B16 melanoma cells indicated that isoprenoid moiety substitutions in flavonoids enhance their cytotoxicity, and that the position of attachment and the number of isoprenoid-substituent moieties per molecule influence flavonoid cytotoxicity.

US$19.90

PMID: 19686821

DOI: 10.1016/j.fitote.2009.08.001


Other references

Balter, M., 2005: Paleoanthropology. Small but smart? Flores hominid shows signs of advanced brain. Science 307(5714): 1386-1389

Wyrzykowska, P.; Kasza, A., 2009: Regulation of PAI-1 expression. PAI-1 (plasminogen activator inhibitor-1) is a member of plasminogen cascade with an inhibitory role in plasmin activation. Plasmin is a protease capable of acting on wide range of substrates and, together with metaloproteinases, is a main proteol...

Bard E.; Hamelin B.; Fairbanks R.G., 1990: Uranium thorium ages obtained by mass spectrometry in corals from barbados west indies sea level during the past 130000 years. Nature (London) 346(6283): 456-458

Kim, H.; Farrand, S.K., 1998: Opine catabolic loci from Agrobacterium plasmids confer chemotaxis to their cognate substrates. Opines are carbon compounds produced by crown galls and hairy roots induced by Agrobacterium tumefaciens and A. rhizogenes, respectively. These novel condensation products of plant metabolic intermediates are utilized as nutritional sources by the...

Mityukov, A.S.; Eskeleva, Z.I., 1988: Economic losses due to infertility of cows. Data were obtained on 20 757 cows from 8 herds. When a calving interval of 1 yr was taken as the standard, the loss in milk yield amounted to 139 kg in cows with low (2500 kg) milk yields and to 316 kg in cows with high (5500 kg) milk yields when...

Asali, I.I.A.u; Reitarova, T.E.; Rozanov, V.A.; Rozanov, A.Y., 1992: Possible involvement of the GABA metabolism system in the mechanisms of protective action of L-aspartate in chamber hypoxia. L-Aspartate given intradermally in a dose of 100 mg cntdot kg-1 to mice 2-3 minutes before placement to a hypoxic chamber was show to prolong the mean animal lifespan by 38% and to delay hypoxic convulsions by 38-40%. The agent was ascertained to...

Cull, D.L.; Parent, F.N.; Wheeler, J.R.; Gregory, R.T.; Snyder, S.O.; Gayle, R.G., 1991: Thoracic aortic ectasia in a patient with Takayasu's disease. Arterial aneurysm formation occurs in 15 to 20% of patients with Takayasu's disease. The timing of surgical intervention of these aneurysms is controversial. A case of ectasia of the descending thoracic aorta in a patient with Takayasu's...

Boddy, K.; King, P.C.; Henderson, J.T.; Shearman, D.J.; Finlayson, N.D.; Simpson, J.D.; Tothill, P., 1972: A direct intercomparison of two whole-body monitors in the measurement of the absorption of an oral dose of vitamin B 12 labelled with 57 Co and 58 Co. Physics in Medicine and Biology 17(3): 374-380

Riquelme Pereira, Náyade.B.; Fraile Duvicq, C.Gloria.; Carvalho, A.Maria.Pimenta., 2006: The influence of psychoactive substance consumption in the family context on students' self-esteem. This study aimed to correlate students' self-esteem in the sixth year of basic education in Chiguayante state schools in Concepción-Chile with psychoactive substance consumption in the family. This non-experimental, correlational and cross-s...

Margaritis, A.; Wilke, C.R., 1978: The rotorfermentor. II. Application to ethanol fermentation. The kinetics of microbial growth and product formation are described as applied to the high cell concentration scheme of the rotorfermentor. A bench scale pilot plant was designed and built in order to demonstrate the operational feasibility of th...