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MAGUK proteins: structure and role in the tight junction

, : MAGUK proteins: structure and role in the tight junction. Seminars in Cell & Developmental Biology 11(4): 315-324

ZO-1, ZO-2 and ZO-3 are tight junction (TJ)-associated proteins that belong to the MAGUK family. In addition to the presence of the characteristic MAGUK modules (PDZ, SH3 and GK), ZOs have a distinctive carboxyl terminal with splicing domains, acidic- and proline-rich regions. The modular organization of these proteins allows them to function as scaffolds, which associate to transmembrane TJ proteins, the cytoskeleton and signal transduction molecules. ZOs shuttle between the TJ and the nucleus, where they may regulate gene expression.


PMID: 10966866

DOI: 10.1006/scdb.2000.0178

Other references

Huffman Alan R.; McCartney Kevin; Loper David E., 1989: Hot spot initiation and flood basalts as a cause of catastrophic climate change and mass extinctions. Abstracts with Programs - Geological Society of America 21(6): 92-A93

Anonymous, 1952: Remarkable malady in young budded Rubber. An unusual type of malformation was observed in two fields of two-year-old rubber buddings of clone R.R.I. 501 in central Perak, Malaya, in 1952. The trunks had developed a distortion, ranging from a barely discernible bend (always near a concentr...

Jose, C.J.; Perez-Cruet, J., 1979: Incidence and morbidity of self-induced water intoxication in state mental hospital patients. American Journal of Psychiatry 136(2): 221-222

Kraemer, J.; Quensel, C.; Gross, M.C.; Cardoso, C.M.; Leonhardt, H., 1999: Identification and characterization of novel smoothelin splice variants. Circulation 100(18 SUPPL ): I 690, Nov 2

Chandra K.J.; Rao K.H., 1984: Pterobothrium russellii new species cestoda trypanorhyncha from a teleost fish pterois russelli of waltair india. Examination of teleosts and invertebrates for larval cestodes from Waltair coast, Bay of Bengal [India] resulted in the recovery of a new species of trypanorhynch larva Pterobothrium russellii encysted in the intestinal wall of a teleost.sbd.Ptero...

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Goyal, A.; Baijal, B., 1979: Genetic diversity of protease activity in some rice varieties in relation to gibberellic acid. Comparative physiology and ecology 4(4): 251-253

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Bellet, D.H.; Wands, J.R.; Isselbacher, K.J.; Bohuon, C., 1984: Serum alpha-fetoprotein levels in human disease: perspective from a highly specific monoclonal radioimmunoassay. A rapid multisite radioimmunoassay for measurement of human alpha-fetoprotein (AFP) that uses two high-affinity monoclonal antibodies directed against distinct and separate determinants on the protein was developed and designated M-RIA. The sensit...