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Magnetic resonance imaging and histology correlations in post - mortem multiple sclerosis brain


, : Magnetic resonance imaging and histology correlations in post - mortem multiple sclerosis brain. Society for Neuroscience Abstract Viewer & Itinerary Planner : Abstract No 213 8

We correlated tissue pathology to various types of post-mortem MRI from 5 secondary progressive multiple sclerosis (MS) patients. Prior to rapid autopsy protocol, the donor underwent a post-mortem in situ MRI which included T2-weighted, T1-weighted and magnetization transfer ratio (MTR) images. Lesions were segmented and classified automatically in the post-mortem MRI. Following imaging, one hemisphere was fixed whole. A post-fixation MRI was performed in a custom-designed slicing box to aid in co-registration of MRI and tissue location. The fixed brain was cut into 1 cm thick coronal slices. 66 areas of interest were selected for immunohistochemical analysis using the following MRI categories: regions that were normal-appearing on all images (N=15); regions of T2 hyperintensity that were normal-appearing on T1 and MTR (T2 only,N=22); and regions of T2 hyperintensity which were hypointense on T1 and MTR (T2T1MTR,N=29). Normal-appearing regions on MRI corresponded to myelinated white matter. 73% of T2 only lesions were demyelinated consisting of 32% active, 27% chronic active and 14% chronic inactive lesions. Some of T2 only had gliosis, loss of phosphorylated neurofilaments, and accumulation of serum proteins. 90% of T2T1MTR were demyelinated consisting of 7% active, 21% chronic active and 62% chronic inactive lesions. Most T2T1MTR had gliosis, loss of phosphorylated neurofilaments and accumulation of serum proteins. Although abnormal MRI categories contained demyelinated areas, T2T1MTR lesions had a higher percentage of chronic inactive areas compared to T2 only lesions. Information about specific MS pathology can be inferred from classification of MRI lesions and may be useful for monitoring MS progression.

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Other references

Piriyaprasarth, P.; Morris, M.E.; Delany, C.; Winter, A.; Finch, S., 2009: Trials needed to assess knee proprioception following stroke. This study explores the number of trials required to identify clinically significant impairments in knee joint position sense and movement sense following stroke. Proprioception was assessed in 33 stroke patients aged 37-87 years. Ten trials for e...

Schubel J.R.; Schiemer E.W., 1972: A device for collecting in-situ samples of suspended sediment for microscopic analysis. Journal of Marine Research: , Pages 269-273. 1972.

Yiannikas, J.; Eastway, R.J.; MacIntyre, W.J.; Maloney, J.D.; Go, R.T.; Cook, S.A.; Sufka, B.; Castle, L.W., 1982: Phase imaging: a new, noninvasive method for diagnosis, localization of accessory pathways, and serial assessment of therapy in patients with Wolff-Parkinson-White syndrome. Cleveland Clinic Quarterly 49(2): 61-72

Jacovella, G.; Floris, B.; Vajola, S.F., 1974: Electrostimulation in acute myocardial infarct complicated by intra-ventricular and atrio-ventricular conduction disorders. Results in 170 personal cases. La Clinica Terapeutica 68(1): 41-57

D'Souza, P., 2016: Notable deals in the pharmaceutical industry in the second quarter of 2016. NlmCategory="UNASSIGNED">During the second quarter of 2016, Cortellis Competitive Intelligence had 1,014 new deals added as part of its ongoing coverage of pharmaceutical licensing activity. This was on par with the last quarter (1,01...

Reynolds, T.E.; Pearse, R.M., 2014: Cardiac troponins in sepsis: an indication for echocardiography?*. Critical Care Medicine 42(4): 975-976

Moreira, I.; Costa, P.M.A.; Pereira, J.A.A.; Cardoso, R.M.; Gomes, S.T.; Mello, H.V. de, 1985: Effect of housing density on the performance of finishing pigs. From 58 kg body weight to slaughter, 432 gilts and barrows were housed in pens with 9, 12, 15 or 18 animals, allowing 0.79, 0.59, 0.47 and 0.39 msuperscript 2 floor space resp. per pig. In the 4 groups, daily gain averaged 776, 763, 718 and 614 g...

Navarrete Álvaro, Mía.Luisa.; Graterol, D.; Rovira, A., 2013: Internal auditory canal lipoma. Acta Otorrinolaringologica Espanola 63(6): 491-492

Ketchem, R.R.; Lee, K.C.; Huo, S.; Cross, T.A., 1996: Macromolecular structural elucidation with solid-state NMR-derived orientational constraints. The complete structure determination of a polypeptide in a lipid bilayer environment is demonstrated built solely upon orientational constraints derived from solid-state NMR observations. Such constraints are obtained from isotopically labeled sam...

Führer, M.; Hammer, J., 2009: Effect of repeated, long term capsaicin ingestion on intestinal chemo- and mechanosensation in healthy volunteers. Repeated ingestion of capsaicin over a prolonged period reduces symptoms in functional dyspepsia, but initially induces upper abdominal symptoms. Sensitizing chemonociception might be the cause for this initial effect of capsaicin. The aim was to...