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Magnetic resonance imaging and histology correlations in post - mortem multiple sclerosis brain

, : Magnetic resonance imaging and histology correlations in post - mortem multiple sclerosis brain. Society for Neuroscience Abstract Viewer & Itinerary Planner : Abstract No 213 8

We correlated tissue pathology to various types of post-mortem MRI from 5 secondary progressive multiple sclerosis (MS) patients. Prior to rapid autopsy protocol, the donor underwent a post-mortem in situ MRI which included T2-weighted, T1-weighted and magnetization transfer ratio (MTR) images. Lesions were segmented and classified automatically in the post-mortem MRI. Following imaging, one hemisphere was fixed whole. A post-fixation MRI was performed in a custom-designed slicing box to aid in co-registration of MRI and tissue location. The fixed brain was cut into 1 cm thick coronal slices. 66 areas of interest were selected for immunohistochemical analysis using the following MRI categories: regions that were normal-appearing on all images (N=15); regions of T2 hyperintensity that were normal-appearing on T1 and MTR (T2 only,N=22); and regions of T2 hyperintensity which were hypointense on T1 and MTR (T2T1MTR,N=29). Normal-appearing regions on MRI corresponded to myelinated white matter. 73% of T2 only lesions were demyelinated consisting of 32% active, 27% chronic active and 14% chronic inactive lesions. Some of T2 only had gliosis, loss of phosphorylated neurofilaments, and accumulation of serum proteins. 90% of T2T1MTR were demyelinated consisting of 7% active, 21% chronic active and 62% chronic inactive lesions. Most T2T1MTR had gliosis, loss of phosphorylated neurofilaments and accumulation of serum proteins. Although abnormal MRI categories contained demyelinated areas, T2T1MTR lesions had a higher percentage of chronic inactive areas compared to T2 only lesions. Information about specific MS pathology can be inferred from classification of MRI lesions and may be useful for monitoring MS progression.


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