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Magnetic resonance imaging in patients with central nervous system pathology A comparison of OptiMARK and Magnevist


, : Magnetic resonance imaging in patients with central nervous system pathology A comparison of OptiMARK and Magnevist. Investigative Radiology 35(7): 412-419, July

RATIONALE AND OBJECTIVES: The objective of the two pivotal phase 3 studies was to evaluate the safety and efficacy of OptiMARK (Gd-DTPA-bis(methoxyethylamide) (Gd-DTPA-BMEA)) compared with Magnevist (Gd-DTPA) in magnetic resonance imaging of the central nervous system. METHODS: Two multicenter, randomized, double-blind, parallel group studies were conducted in 395 patients with known or suspected central nervous system pathology. Subjects were randomized to receive a single 0.1 mmol/kg intravenous injection of either Gd-DTPA-BMEA or Gd-DTPA. The safety of Gd-DTPA-BMEA and Gd-DTPA was monitored for up to 72 hours after study drug administration. Precontrast and postcontrast administration magnetic resonance scans were acquired using identical imaging planes and techniques. RESULTS: No deaths or unexpected adverse events were reported in either group. A comparison of adverse events by intensity and relation demonstrated no statistically significant differences between the two groups. Gd-DTPA-BMEA and Gd-DTPA were equivalent with respect to confidence in diagnosis, conspicuity, and border delineation. CONCLUSIONS: Gd-DTPA-BMEA and Gd-DTPA demonstrated comparable efficacy profiles, and the safety profiles were considered similar.

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Other references

Whitlock, F.L., 1940: Notes on the Thick-billed Thombill. Emu Melbourne, 39: 176-178

Kalra, P.S.; Crowley, W.R.; Kalra, S.P., 1987: Differential in vitro stimulation by naloxone and K+ of luteinizing hormone-releasing hormone and catecholamine release from the hypothalami of intact and castrated rats. Evidence is presented which suggests that stimulation of LH release by naloxone in [male] rats may be mediated by increased release of catecholamines and LHRH, and that LHRH, noradrenaline and possibly adrenaline release in vivo may be diminished...

Watney Lynn; French John; Heckel Philip; Franseen Evan, 1993: Stop 6; Roadcuts along I-435 near Holliday Road exit; section from Chanute Shale to Stanton Limestone. Open-File Report - Kansas Geological Survey Pages 105-114

Tupper, G.; Bridge, R.; Ebelhar, M., 1992: Variety response to surface, deep banded, and split applicaitons of potassium. Proceedings Beltwide Cotton Conferences(3): 1139-1142

Johnson S.A.; Finch C.E., 1987: Cloning of rna sequences whose prevalence is increased in alzheimer cortex. Society for Neuroscience Abstracts 13(2): 1325

Kato, H.; Galiñanes, M.; Elliott, M.J.; de Leval, M.R.; Hearse, D.J., 1994: Comparison of single- and multi-dose crystalloid cardioplegia to protect the immature myocardium. The primary objective of this study was to compare the protective effects of single-dose and multi-dose St. Thomas' Hospital cardioplegic solution number 1 in the ischemic and reperfused neonatal rabbit heart. In addition, the effect of inclu...

Ivarsson, T.; Larsson, B., 2008: The Obsessive-Compulsive Symptom (OCS) scale of the Child Behavior Checklist: a comparison between Swedish children with Obsessive-Compulsive Disorder from a specialized unit, regular outpatients and a school sample. To evaluate the discriminative power of various items as reported by parents in the OCS-scale extracted from the Child Behavior Checklist (CBCL) problem scale and to compare findings with outcomes of previous validation studies. Children referred...

Sinnott, C., 2010: Program-wide behavior support plans for programs serving students who are deaf or hard of hearing in Illinois. Positive Behavior Interventions and Supports (PBIS) programs are being introduced in school districts throughout Illinois and the rest of the United States, resulting in decreased behavioral incidents and increased academic achievement. Programs f...

Stack, R.R.; Thompson, A.M.; Weatherhead, R.G.; Pithie, A., 2008: The levator aponeurosis exposed. A case of bilateral upper eyelid ptosis in an HIV-infected patient with severe antiretroviral-associated facial lipodystrophy is presented. The features, treatment, and outcome are discussed. Dehiscence of the levator aponeurosis may be directly a...

Planterose, D.N.; Dewdney, J.M.; Spackman, D.A.; Currie, G.A.; Cornbleet, M.A., 1981: Ds RNAs from natural sources: induction of interferon and toxicity in baboons and man. Texas Reports on Biology and Medicine 41: 144-149