+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Magnetic resonance imaging of multiple sclerosis: new insights linking pathology to clinical evolution

, : Magnetic resonance imaging of multiple sclerosis: new insights linking pathology to clinical evolution. Current Opinion in Neurology 14(3): 279-287

Magnetic resonance imaging methods allow observation of pathological changes in vivo. Magnetic resonance-based studies have provided a number of important insights into the spatio-temporal evolution of the pathology of multiple sclerosis in vivo, particularly with respect to the relation between pathology and progression of disability. Magnetic resonance techniques have shown that this pathology is not restricted to the plaques that are evident at autopsy, but also involve the so-called normal-appearing white matter. Nonconventional magnetic resonance imaging strategies such as magnetization transfer imaging and spectroscopic imaging provide measures with higher pathological specificity for myelin and axonal injury. These and other advanced magnetic resonance techniques (such as the measurement of atrophy, lesion relaxation spectra, and lesion dynamics) are affording opportunities to use observations of patients to test biologically specific hypotheses. This should help us to better define new targets for drug therapy and to assess responses to new therapeutic agents.


PMID: 11371749

DOI: 10.1097/00019052-200106000-00004

Other references

Beissert, M.; Jenett, M.; Kessler, C., 2001: Diagnosis of space-occupying lesions of the liver. What is the value of diagnostic imaging?. Ultrasound in B-mode or tissue harmonic imaging is the procedure of first choice for investigating the liver. If US is employed to screen for metastatic disease, B-mode contrast harmonic imaging should be used in addition to conventional ultrasoun...

Trisurat, Y.; Chimchome, V.; Pattanavibool, A.; Jinamoy, S.; Thongaree, S.; Kanchanasakha, B.; Simcharoen, S.; Sribuarod, K.; Mahannop, N.; Poonswad, P., 2013: An assessment of the distribution and conservation status of hornbill species in Thailand. Many hornbill species in Thailand are categorized as Endangered or Critically Endangered on the IUCN Red List. The objectives of this research were to predict hornbill distributions in Thailand and to assess the national conservation status of the...

Rauramo, L., 1959: Photocolposcopy. Duodecim; Laaketieteellinen Aikakauskirja 75: 551-558

He, H-mei.; Long, C-liang.; Wang, H., 2012: Regulatory effects of nucleotides on ATP-sensitive potassium channel opener pinacidil-induced vascular relaxation. In order to evaluate the regulatory effects of nucleotides and adenosine on ATP-sensitive potassium channel (K(ATP)) in artery smooth muscles, the effects of them on vascular relaxation induced by K(ATP) opener pinacidil(Pin) were investigated. Th...

Li, C.; Wen, T-Fu.; Yan, L-Nan.; Li, B.; Yang, J-Ying.; Wang, W-Tao.; Xu, M-Qing.; Wei, Y-Gang., 2011: Predictors of patient survival following living donor liver transplantation. Living donor liver transplantation (LDLT) is considered to be the alterative choice in light of the great shortage of cadaveric donors. However, the characteristics of the patients who will benefit from LDLT have not been well identified. The aim...

Björnelius, E.; Jensen, Jørgen.Skov.; Lidbrink, P., 2004: Conjunctivitis associated with Mycoplasma genitalium infection. Conjunctival and first-void urine specimens from a patient with unilateral conjunctivitis and urethritis were found to be positive for Mycoplasma genitalium but negative for Chlamydia trachomatis, by polymerase chain reaction analysis. Identical M...

Lauridsen, L.H.; Shamaileh, H.A.; Edwards, S.L.; Taran, E.; Veedu, R.N., 2013: Rapid one-step selection method for generating nucleic acid aptamers: development of a DNA aptamer against α-bungarotoxin. Nucleic acids based therapeutic approaches have gained significant interest in recent years towards the development of therapeutics against many diseases. Recently, research on aptamers led to the marketing of Macugen®, an inhibitor of vascular e...

Kunkel, R.H.lstad, N.; Mcneal, B., 1977: Comparison of some nitrogen sources for potatoes. Proceedings of annual Washington Potato Conference and Trade Fair: 6th 31-37

LaChance, L.E.; Leopold, R.A., 1969: Cytogenetic effect of chemosterilants in house fly sperm: incidence of polyspermy and expression of dominant lethal mutations in early cleavage divisions. Canadian Journal of Genetics and Cytology. Journal Canadien de Genetique et de Cytologie 11(3): 648-659

Aliperta, A.; Vasaturo, G., 1964: Elementary Structure And Growth Of Bronchopulmonary Mycetomas. Archivio di Tisiologia E Delle Malattie Dell'apparato Respiratorio 19: 54-72