+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Magnetic resonance imaging presentation of lytic Paget's disease of the cervical spine

, : Magnetic resonance imaging presentation of lytic Paget's disease of the cervical spine. Journal of Bone and Mineral Research 17(11): 1929-1930

On June 26-27, 2001, the Sixth Research Roundtable in Multiple Myeloma, entitled "The Role of the Bone Microenvironment in Multiple Myeloma," was held and focused on the biology of cell-to-cell interactions, the mediators of bone disease, and novel treatment strategies for myeloma. Studies on cell-cell interactions showed that vascular cell adhesion molecule 1, expressed by local endothelial and stromal cells, binds to tumor cell surface integrins in which expression may be increased by tumor cell-derived chemokines such as macrophage inflammatory protein (MIP) 1alpha. These adhesive interactions increase production and release of vascular endothelial growth factor (VEGF). Studies on myeloma bone disease showed the ligand for receptor activator of nuclear transcription factor-kappaB (RANKL) was expressed on tumor cells and stromal cells associated with myeloma cells and was critical for osteoclast-induced osteolysis. Blockade of RANKL suppressed osteoclast maturation, bone resorption, and tumor development. Bisphosphonates, in addition to reducing osteoclast mobility and inducing osteoclast apoptosis, also decreased tumor cell adhesion to stroma. Immunomodulatory drugs such as thalidomide analogues targeted these tumor cell-stromal cell interactions, blocking both secretion of cytokines and activation of intracellular signaling pathways required for tumor survival and growth. These agents induced tumor cell apoptosis, decreased neovascularization, and potentiated natural killer cell activity. The proteasome inhibitor PS-341 also prevented expression of adhesion molecules and cytokines and triggered tumor cell apoptosis, even in drug-resistant cell lines, while showing minimal activity in healthy cells. In addition, potential therapeutic agents under investigation, which included RANKL antagonists, protein prenylation inhibitors, and osteoblast growth factors, were discussed.


PMID: 12412798

DOI: 10.1359/jbmr.2002.17.11.1929

Other references

Yang, H.; Deng, J.; Jiang, Y.; Chen, J.; Zeng, X.; He, Z.; Jiang, X.; Li, Z.; Jiang, C., 2016: Emulsified isoflurane treatment inhibits the cell cycle and respiration of human bronchial epithelial 16HBE cells in a p53-independent manner. Emulsified isoflurane (EIso), as a result of its rapid anesthetic induction, recovery and convenience, is widely used as a novel intravenous general anesthetic. Treatment with EIso can reduce injuries caused by ischemia/reperfusion (I/R) to organs...

Johnson, Jd, 1977: Pecan spraying secret to successful pecan production. Pecan South: 4 (1) 12-13

Rand, J.H.; Wu, X.X., 1999: Antibody-mediated disruption of the annexin-V antithrombotic shield: a new mechanism for thrombosis in the antiphospholipid syndrome. Thrombosis and Haemostasis 82(2): 649-655

Manjarrez, Ruben Breton, 1953: Sterochemical configuration in chloramphenicol. Antibiotic activity was observed only in the levo-rotatory fraction of chloramphenicol while the dextro-rotatory fraction was not only inactive but actually toxic.

Moede, Ruby B., 1933: The influence of iodoacetic acid poisoning upon oxygen consumption of striated muscle. Resting muscle treated with mono-iodoacetic acid showed no specific increase in O2 consumption, regardless of the occurrence or non-occurrence of rigor. A frequent result of iodoacetic acid treatment is a progressive decrease in O2 consumption.

Toni, R.; Casa, C.Della.; Bodria, M.; Spaletta, G.; Vella, R.; Castorina, S.; Gatto, A.; Teti, G.; Falconi, M.; Rago, T.; Vitti, P.; Sgallari, F., 2008: A study on the relationship between intraglandular arterial distribution and thyroid lobe shape: implications for biotechnology of a bioartificial thyroid. We have recently hypothesized that structural and secretory components of the adult human thyroid gland maintain constant reciprocal and geometrical relationships, even if changes occur in the three-dimensional (3D) architecture of any of these el...

Gossman, H.H., 1968: New equipment. Journal of the Royal College of Surgeons of Edinburgh 13(3): 167-167

Satterlee L.D.; Koller H.R., 1984: Response of soybean glycine max cultivar wells fruit respiration to changes in whole plant light and carbon dioxide environment. A nondestructive indicator of instantaneous seed growth rate in soybean and other legumes would be useful in studies of the physiology of seed growth. The responsiveness of soybean fruit respiration rate to whole plant environmental treatments kno...

Carlotti, A.P.C.P.; Bohn, D.; Mallie, J.P.erre; Halperin, M.L., 2000: Comparison of an electrolyte-free water and a tonicity balance Which provides the best way to determine why the plasma sodium concentration changed and its treatment?. Background: Electrolyte-free water (EFW) terms are commonly used to decide why the PNa changed and to plan goals for its therapy. Objective: To evaluate whether an EFW balance reveals the basis for a change in PNa and what treatment measures are n...

Leiper, J.B., 1997: The use of beverages as ergogenic acids. Reilly, T [Editor], Orme, M [Editor] International Congress Series; The clinical pharmacology of sport and exercise 233-241