geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Making memories stick: cell-adhesion molecules in synaptic plasticity


, : Making memories stick: cell-adhesion molecules in synaptic plasticity. Trends in Cell Biology 10(11): 473-482

Synapses are adhesive junctions highly specialized for interneuronal signalling in the central nervous system. The strength of the synaptic signal can be modified (synaptic plasticity), a key feature of the cellular changes thought to underlie learning and memory. Cell-adhesion molecules are important constituents of synapses, with well-recognized roles in building and maintaining synaptic structure during brain development. However, growing evidence indicates that cell-adhesion molecules also play important and diverse roles in regulating synaptic plasticity and learning and memory. This review focuses on recent advances in understanding the molecular mechanisms through which adhesion molecules might regulate synaptic plasticity.

US$19.90

PMID: 11050419

DOI: 10.1016/s0962-8924(00)01838-9


Other references

Balon, R., 1989: Biological predictors of antidepressant treatment outcome. Clinical Neuropharmacology 12(3): 195-214

Pickup, John, C., 2006: Long-term use of continuous subcutaneous insulin infusion. The routine clinical use of insulin pump therapy (continuous subcutaneous insulin infusion, CSII) is very variable throughout the world - from 20% to less than 1 % of type 1 diabetic subjects. One reason for this is the continued confusion about...

Pruksa, S.; Siripinyanond, A.; Powell, J.J.; Jugdaohsingh, R., 2014: Silicon balance in human volunteers; a pilot study to establish the variance in silicon excretion versus intake. Accumulating evidence suggests a role for silicon in optimal connective tissue health. Further proof of its importance/essentiality may be provided by studies involving imposed depletion followed by 29Si challenge to estimate metabolic balance. Pr...

Elford, B.C.; Pinches, R.A.; Newbold, C.I.; Ellory, J.C., 1990: Heterogeneous and substrate-specific membrane transport pathways induced in malaria-infected erythrocytes. Blood Cells 16(2-3): 433-436

Azuara, Véronique.; Fisher, A.G., 2003: Maintaining transcriptional states through DNA replication. The timing of DNA replication has been implicated in gene regulation based on observations that actively transcribed genes generally replicate earlier in S-phase than their inactive counterparts. However, we recently showed that differentiation-in...

Cassidy S.S.; Johnson R.L.Jr; Mitchell J.H., 1977: Right and left ventricular pressure and volume changes during positive end expiratory pressure. Physiologist 20(4): 14

Hawkins, R.A.; Hill, A.; Freedman, B.; Gore, S.M.; Roberts, M.M.; Forrest, A.P.M., 1977: Reproducibility of measurements of estrogen receptor concentration in breast cancer. The reproducibility of measurements of estrogen receptor activity was examined in multiple specimens from a rabbit uterus, a rat mammary tumor and human breast tumors. The relationship between receptor concentration and tumor histology was also in...

Ndidi, U.Samuel.; Ndidi, C.Unekwuojo.; Olagunju, A.; Muhammad, A.; Billy, F.Graham.; Okpe, O., 2014: Proximate, Antinutrients and Mineral Composition of Raw and Processed (Boiled and Roasted) Sphenostylis stenocarpa Seeds from Southern Kaduna, Northwest Nigeria. This research was aimed at evaluating the proximate composition, level of anti-nutrients, and the mineral composition of raw and processed Sphenostylis stenocarpa seeds and at examining the effect of processing on the parameters. From the proximat...

Edwards, P., 1996: Massive choroidal hemorrhage in age-related macular degeneration: a complication of anticoagulant therapy. Age-related macular degeneration (ARMD) is the leading cause of legal blindness in the elderly, causing profound loss of central vision. A 90-year-old patient with exudative age-related macular degeneration who had been placed on anticoagulant the...

Sourbron, S.P.; Buckley, D.L., 2014: Classic models for dynamic contrast-enhanced MRI. Dynamic contrast-enhanced MRI (DCE-MRI) is a functional MRI method where T1 -weighted MR images are acquired dynamically after bolus injection of a contrast agent. The data can be interpreted in terms of physiological tissue characteristics by app...