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Mechanisms of granulocyte colony-stimulating factor-induced hematopoietic progenitor-cell mobilization

, : Mechanisms of granulocyte colony-stimulating factor-induced hematopoietic progenitor-cell mobilization. Seminars in Hematology 37(1 Suppl 2): 25-32

Hematopoietic progenitor cells (HPC) can be mobilized from the bone marrow into the peripheral circulation in response to diverse stimuli, including hematopoietic growth factors, cytotoxic agents, and certain chemokines. Despite significant differences in their biologic activities, these stimuli result in the mobilization of HPC with a similar phenotype, suggesting that a common mechanism for mobilization may exist. To explore the mechanisms of granulocyte colony-stimulating factor (G-CSF)-induced mobilization, we examined HPC mobilization in mice that are genetically deficient for the G-CSF receptor (G-CSFR). Their response was determined to each of three major types of mobilizing stimuli: cytotoxic agents (cyclophosphamide), chemokines (Interleukin-8[IL-8]), and hematopoietic growth factors (G-CSF, fit-3 ligand, and IL-12). These studies demonstrate that the G-CSFR is required for mobilization in response to cyclophosphamide and IL-8, but not fit-3 ligand or IL-12, and suggest that the G-CSFR may play an important and previously unexpected role in HPC migration.


PMID: 10718156

DOI: 10.1016/s0037-1963(00)90086-6

Other references

Anonymous, 2017: Fifty-Seventh Annual Meeting of the Society for Psychophysiological Research The Hofburg, Vienna, Austria October 11-15, 2017 Website: Psychophysiology 54 Suppl 1: S1-S1

Gentile, A.; Florino, A.; Crispi, G.; Pannone, B.; D.L.renzo, R.; Sciorio, G.; Caruso, C., 1975: Mental disturbances in multiple sclerosis. Pathogentic mechanisms. Acta Neurologica 30(4): 404-410

Kennon, S.; Barakat, K.; Hitman, G.A.; Price, C.P.; Mills, P.G.; Ranjadayalan, K.; Cooper, J.; Clark, H.; Timmis, A.D., 2001: Angiotensin-converting enzyme inhibition is associated with reduced troponin release in non-ST-elevation acute coronary syndromes. OBJECTIVES This study was done to determine the effects of angiotensin-converting enzyme (ACE) inhibition and other clinical factors on troponin release in non-ST-elevation acute coronary syndrome (ACS). BACKGROUND Troponin is now widely used as a...

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Chagirov, I.; D'-Iachenko, O.; Mal'-Chenko, A., 1983: Growth and development of the fetuses of crossbred sheep. Trudy Instituta Eksperimental'noi Biologii Akademiia nauk Kazakhskoi SSR6(16): 247-257

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