+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Modulation of behavioral responses during the forced swim test the role of interleukin 1

, : Modulation of behavioral responses during the forced swim test the role of interleukin 1. Society for Neuroscience Abstract Viewer & Itinerary Planner : Abstract No 576 5

In recent years, there has been increasing recognition that pro-inflammatory cytokines may play a role in behavioral and physiological alterations produced by exposure to psychological stressors. Indeed, increases in central IL-1 production have been observed following stressors such as inescapable tailshock and social isolation, while no changes in IL-1 have been observed following other stressors (eg., exposure to a predator). The goal of the following work was to establish (a) whether forced swim exposure leads to an increase in central production of IL-1, and (b) determine whether the immobility response observed during forced swim exposure is modulated by pro-inflammatory cytokine production. Briefly, adult male Sprague Dawley rats (n=8 per group) were forced to swim for 15-30 minutes (25degreeC) and killed at various intervals (ranging from immediately to 24 hrs) following stressor termination. Brains were then dissected and frozen for subsequent measurement of IL-1. No observable increases in IL-1 were observed in rats that were forced to swim, or in rats that were re-exposed to the forced swim stressor 24 hrs later. These data suggest that central IL-1 production does not play a role in behavioral responses to forced swim stress. However, these data do not exclude a possible role for other pro-inflammatory cytokines (such as IL-6 and TNF-alpha) in the generation of behavioral responses to forced swim. The potential role of pro-inflammatory cytokine production in the modulation of behavioral responses to forced swim is currently in progress.


Other references

Cozens, RD., 1987: Second broods of Pissodes strobi (Coleoptera: Curculionidae) in previously attacked leaders of interior spruce. The biology of Pissodes strobi was studied in a 15-year-old plantation of interior spruce (Picea glauca X P. engelmannii) in British Columbia in 1984-86. Oviposition and successful brood production were observed below the previous year's atta...

Pierre, J.F., 2017: Gastrointestinal immune and microbiome changes during parenteral nutrition. Parenteral nutrition (PN) is a lifesaving therapy that provides intravenous nutrition support to patients who cannot, or should not, feed via the gastrointestinal (GI) tract. Unfortunately, PN also carries certain risks related to infection and me...

Hill, K.D.; Johnson, L.A.S., 1995: Systematic studies in the eucalypts 7. A revision of the bloodwoods, genus Corymbia (Myrtaceae). A taxonomic revision of the bloodwoods (including the 'ghost gums') is presented. Previous cladistic studies in the eucalypts are re-evaluated; new phylogenetic analyses are presented for the Angophora + Eucalyptus s.l. group, the Angoph...

Halperin, J.M., 1991: The clinical assessment of attention. International Journal of Neuroscience 58(3-4): 171-182

Shah, S.; Saxena, D., 2014: Bilateral papilledema: A case of cerebral venous sinus thrombosis. Oman Journal of Ophthalmology 7(1): 33-34

Cales, P., 1969: Preoperative examination and directions for implants. Revue Odonto-Implantologique 16: 28-35

Hess, A.D.; Colombani, P.N., 1987: Cyclosporin-resistant and -sensitive T-lymphocyte subsets. Annales de L'institut Pasteur. Immunology 138(4): 606-611

Gago, S.; Zaragoza, Óscar.; Cuesta, I.; Rodríguez-Tudela, J.L.; Cuenca-Estrella, M.; Buitrago, Mía.J., 2012: High-resolution melting analysis for identification of the Cryptococcus neoformans-Cryptococcus gattii complex. We have developed a two-step method based on high-resolution melting (HRM) that reliably identifies species from the Cryptococcus species complex (Cryptococcus neoformans var. grubii, Cryptococcus neoformans var. neoformans, and Cryptococcus gatti...

Anonymous, 1986: German measles. Medical Journal of Australia 144(7): 391-392

Borges, E.; Cognato,; Vuaden, F.Cenci.; Bogo, Mício.Reis.; Fauth, M.da.Graça.; Bonan, C.Denise.; Dias, R.Dutra., 2004: Nucleotidase activities in membrane preparations of nervous ganglia and digestive gland of the snail Helix aspersa. Nucleotide-metabolizing enzymes play an important role in the regulation of nucleotide levels. In the present report, we demonstrated an enzyme activity with different kinetic properties in membrane preparations of the nervous ganglia and digestiv...