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Modulation of mammalian telomerase by peptide nucleic acids


, : Modulation of mammalian telomerase by peptide nucleic acids. Official Gazette of the United States Patent & Trademark Office Patents 1230(3), Jan 18

The invention relates to peptide nucleic acids that inhibit telomerase activity in mammalian cells.

US$29.90


Other references

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Tuman, R.W.; Doisy, R.J., 1977: Metabolic effects of the glucose tolerance factor (GTF) in normal and genetically diabetic mice. The acute metabolic effects of glucose tolerance factor (GTF), the biologically active form of trivalent chromium, were studied in normal and genetically diabetic (db/db) mice. A single intraperitoneal injection of GTF significantly reduced the no...

Bernheim, H.A., 1986: Is prostaglandin E2 involved in the pathogenesis of fever? Effects of interleukin-1 on the release of prostaglandins. Interleukin-1 (IL-1) induces the formation of PGE2 from monocytes, fibroblasts, muscle cells, and brain tissue by increasing the intracellular concentrations of CA2+; this cation, in turn, activates a phospholipase which cleaves arachidonic acid f...

Zhang, Z.; Cohen, D.M., 1997: Hypotonicity increases transcription, expression, and action of Egr-1 in murine renal medullary mIMCD3 cells. In cells of the murine renal inner medullary collecting duct (mIMCD3) cell line, acute hypotonic shock (50% dilution of medium with sterile water but not with sterile 150 mM NaCl) increased Egr-1 mRNA abundance 2.5-fold at 6 h, as determined by No...

Ota, K., 1989: Towards an ideal polyurethane graft for hemodialysis. Numerous studies have been reported in the field of vascular graft in recent years. The main interest in these studies has focused on producing either a small diameter arterial graft or prosthesis for veins. Polyurethane polymers are emerging beca...

D.Stigter, H.C.M., 1969: Growth relations between individual fruits, and between fruits and roots in cucumber. In a severely pruned "shoot-fruit-root" system pronounced relations were observed between individual fruits and between root and fruit growth, viz. the dominance of a single fruit, usually the first, over subsequent fruits with marked in...

Pratt, F.L.; Baker, P.J.; Blundell, S.J.; Lancaster, T.; Green, M.A.; Kurmoo, M., 2007: Chiral-like critical behavior in the antiferromagnet cobalt glycerolate. Critical exponents closely matching those of the N=2 chiral universality class have been obtained for the layered magnetic system cobalt glycerolate using muon spin relaxation. This class was originally introduced to represent geometrically frustr...

Dubowchik, G.M.; Ditta, J.L.; Provencal, D.P.; Denhart, D.J., 2001: Neurotrophic diamide and carbamate agents. The present invention relates to the design, synthesis, and the peptidyl-prolyl isomerase (PPIase or rotamase) inhibitory activity of novel pyrrolidinemethyl diamide and carbamate compounds that are neurotrophic agents (i.e. compounds capable of s...

Li, L.; Shao, C.; Song, W.; Lynn, D.H.; Chen, Z.; Shin, M.Kyoon., 2009: Does Kiitricha (Protista, Ciliophora, Spirotrichea) belong to Euplotida or represent a primordial spirotrichous taxon? With suggestion to establish a new subclass Protohypotrichia. The genus Kiitricha was long assumed to be the most primordial taxon in the Stichotrichia [hypotrichs sensu lato (s. l.)] based on its morphological features and was considered to be an intermediate between heterotrichs and the traditional hypotri...

Huffman, S.A.; Veen, J.; Hennink, M.M.; McFarland, D.A., 2012: Exploitation, vulnerability to tuberculosis and access to treatment among Uzbek labor migrants in Kazakhstan. In recent years, Kazakhstan has become an important destination for primarily undocumented seasonal workers from Uzbekistan. In a context of high tuberculosis (TB) incidence, TB treatment is provided free for all residents in Kazakhstan, but migra...